Geissoschizin | 118577-70-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 柯楠因类生物碱
• 英文名称: Geissoschizin
• 英文别名: methyl 2-[(2R,3E,12bS)-3-ethylidene-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-oxopropanoate
• CAS: 118577-70-1
• 化学式: C₂₁H₂₄N₂O₃
• 分子量: 352.433
• InChiKey: AUOFTPXWUVYOOQ-VJBMQPMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 Geissoschizin
  参考文献：
  名称：

  Bertho et al., Chemische Berichte, 1958, vol. 91, p. 2581,2588

  摘要：

  DOI：

文献信息

• A method for preparing a cell free homogenate of Chrysanthemum cinerariaefolium (Trev.) Bocc.
  申请人：McLAUGHLIN GORMLEY KING COMPANY

  公开号：EP0124049A2

  公开（公告）日：1984-11-07

  A method for preparing a cell free homogenate containing bioactive enzyme(s) and cofactor(s) of the pyrethrin pathway of Chrysanthemum cinerariaefolium (Trev.) Bocc. is provided. This cell free homogenate will convert mevalonic acid or isopentenyl pyrophosphate into pyrethrins and chrysanthemyl alcohol.

  提供了一种制备无细胞匀浆的方法，该匀浆含有 Chrysanthemum cinerariaefolium (Trev.) Bocc.除虫菊酯途径中的生物活性酶和辅助因子。这种无细胞匀浆可将甲羟戊酸或焦磷酸异戊烯酯转化为除虫菊酯和菊醇。
• PHOTOCHEMICAL INTERMOLECULAR AMINATION METHOD
  申请人：Fundació Institut Català d'Investigació Química (ICIQ)

  公开号：EP3712128A1

  公开（公告）日：2020-09-23

  Problem: The present invention solves the problem of providing an alternative metal-free method for intermolecular amination of C-H bonds applicable to a broad range of substrates, wherein the substrate is essentially in stoichiometric amounts with respect to the amination reagent. Solution: The present invention relates to a photochemical method for the intermolecular coupling of an amination agent with a compound comprising a fragment of formula -Ca-H, said method converting the fragment of formula - Ca-H in a fragment of formula -Ca-NSO2R1, and comprising the step of contacting under light irradiation and in an aprotic solvent an amination agent with a compound comprising a fragment of formula -Ca-H in the presence of a compound of formula (I)          Arl(O2CR3)2     (I) and a catalytically effective amount of iodine wherein the amination agent is selected from the compounds of formula R1SO2NHR2 and the compounds of formula R1SO2N=IR2'.

  问题：本发明要解决的问题是提供一种适用于多种底物的 C-H 键分子间胺化的无金属替代方法，其中底物与胺化试剂的量基本上成比例。 解决方案本发明涉及一种将胺化剂与包含式-Ca-H片段的化合物进行分子间偶联的光化学方法，所述方法将式-Ca-H片段转化为式-Ca-NSO2R1片段，并包括以下步骤：在光照射下，在无相溶剂中，在式(I)化合物存在的情况下，将胺化剂与包含式-Ca-H片段的化合物接触。 Arl(O2CR3)2 (I) 和催化有效量的碘，其中胺化剂选自式 R1SO2NHR2 化合物和式 R1SO2N=IR2' 化合物。
• Pharmaceutical composition for treating cancer and a method thereof
  申请人：King Abdulaziz University

  公开号：US10292972B1

  公开（公告）日：2019-05-21

  A pharmaceutical composition containing an anticancer compound, named isopicrinine, isolated from the plant Rhazya Stricta. The pharmaceutical composition may contain a salt, an analog, a derivative, and/or the prodrug of isopicrinine. A method of treating cancer with the pharmaceutical composition is disclosed. A method of extracting isopicrinine is also disclosed.

  一种药物组合物，含有一种从植物 Rhazya Stricta 中分离出来的抗癌化合物，名为异opicrinine。该药物组合物可包含盐、类似物、衍生物和/或异西匹克宁的原药。公开了一种用该药物组合物治疗癌症的方法。还公开了一种提取异西匹克宁的方法。
• Compositions and methods for making terpenoid indole alkaloids
  申请人：Willow BioSciences Inc.

  公开号：US11072613B2

  公开（公告）日：2021-07-27

  Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.

  提供了可用于制造一类称为萜类吲哚生物碱（包括他巴戟碱和卡他蒽碱）的化合物的方法。此外，还提供了用于合成萜类吲哚生物碱（包括他巴戟碱和卡他林碱）的组合物。所提供的化合物可用于制造化疗药物。
• Methods for conducting assays for enzyme activity on protein microarrays
  申请人：Zhou X. Fang

  公开号：US20050118665A1

  公开（公告）日：2005-06-02

  The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.

  本发明涉及在微阵列上进行酶活性测定的方法，这种方法可用于蛋白质功能的大规模研究、筛选测定和酶反应的高通量分析。本发明涉及使用蛋白质芯片检测蛋白质芯片上蛋白质样品中酶的存在、数量、活性和/或功能的方法。特别是，本发明的方法涉及使用芯片进行酶测定，其中蛋白质和物质被固定在固体支持物表面，蛋白质和物质相互靠近，足以使物质和蛋白质之间发生酶反应。本发明还涉及在其表面固定有酶和底物的微阵列，其中酶和底物相互靠近，足以使酶和底物之间发生酶反应。