disodium;1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-[hydroxy(oxido)phosphoryl]oxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyridin-1-ium-3-carboximidate | 24292-60-2

• 物质功能分类: 生物化工 - 酶及辅酶类
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: disodium;1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-[hydroxy(oxido)phosphoryl]oxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyridin-1-ium-3-carboximidate
• CAS: 24292-60-2
• 化学式: C21H26N7Na2O17P3
• 分子量: 787.4
• InChiKey: WSDDJLMGYRLUKR-WUEGHLCSSA-L

物化性质

• 熔点：
  175-178 °C
• 密度：
  1.66g/cm3 at 20℃
• 溶解度：
  DMSO（少许）、水（少许）
• LogP：
  -4.4 at 20℃ and pH7
• 表面张力：
  73.2mN/m at 1g/L and 20℃

计算性质

• 辛醇/水分配系数(LogP)：
  -10.79
• 重原子数：
  50
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  373
• 氢给体数：
  6
• 氢受体数：
  21

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S22,S24/25,S26,S36,S37/39
• 危险类别码：
  R36/37/38
• WGK Germany：
  1,3
• 海关编码：
  29349990
• RTECS号：
  CM4310500
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Name:	Triphosphopyridine Nucleotide Disodium Salt Material Safety Data Sheet
Synonym:	beta-Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt; NADP Disodium Sal
CAS:	24292-60-2

Section 1 - Chemical Product MSDS Name:Triphosphopyridine Nucleotide Disodium Salt Material Safety Data Sheet
Synonym:beta-Nicotinamide Adenine Dinucleotide Phosphate Disodium Salt; NADP Disodium Sal

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
24292-60-2	Triphosphopyridine Nucleotide, Disodiu	ca. 100	246-129-8

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4C/39F.)

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 24292-60-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: >50 g/l water
Specific Gravity/Density:
Molecular Formula: C21H26N7O17P3Na2
Molecular Weight: 787.4

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 24292-60-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Triphosphopyridine Nucleotide, Disodium Salt - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 24292-60-2: 1
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 24292-60-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 24292-60-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

简介

β-烟酰胺腺嘌呤二核苷酸磷酸二钠盐是一种白色或类白色的固体，属于辅酶类物质。NADP二钠常用于酶催化制备2,4-二氨基丁酸的方法。

作用机制

β-烟酰胺腺嘌呤二核苷酸（NAD）和β-烟酰胺腺嘌呤二核苷酸磷酸（NADP）是细胞能量代谢不可或缺的辅酶，在能量代谢中扮演核心角色。此外，嘌呤核苷酸在生物过程中也起到重要的传递作用，能量反应中的质子通常先被传递至NAD和NADP，再还原成NADH和NADPH，并通过电子传输至氧并释放能量。生成的还原性NADH和NADPH是谷胱甘肽还原酶的辅酶，具有重要的抗氧化功能。

检测方法

一种β-NADP二钠盐含量及有关物质（如NAD、ATP、ADP）的测定方法包括以下步骤：

1. 取sigma对照品beta-烟酰胺腺嘌呤二核苷酸磷酸二钠盐用稀释剂溶解成浓度为1mg/ml的对照品溶液；取样品同样溶解成浓度为0.5mg/ml的供试品溶液。
2. 分别取对照品溶液和供试品溶液各20ul，注入液相色谱仪中，记录β-烟酰胺腺嘌呤二核苷酸磷酸二钠盐的峰面积，按照外标法定量，以无水beta-烟酰胺腺嘌呤二核苷酸磷酸二钠盐计算HPLC含量，不应低于98%。
3. 分别取sigma对照品NAD、ATP、ADP用流动相溶解成浓度为5ug/ml、2.5ug/ml、2.5ug/ml的杂质对照品溶液；同时取样品用流动相溶解成浓度为0.5mg/ml的样品溶液。
4. 分别取NAD、ATP、ADP的杂质对照品溶液各20ul，注入液相色谱仪中，记录其峰面积，并按照外标法计算β-烟酰胺腺嘌呤二核苷酸磷酸二钠盐样品中的NAD、ADP和ATP含量。其中，NAD不超过1.0%，ADP不超过0.5%，ATP也应不超过0.5%。

生物活性

Triphosphopyridine nucleotide (NADP) 可在NADP+和NADPH之间交替氧化、切换状态，在很多生物反应中作为电子载体。

用途

烟酰胺腺嘌呤二核苷酸磷酸（NADP）与NADPH形成氧化还原对，是许多辅酶经由电子传输支持的氧化还原反应的关键。尤其是在厌氧反应如脂质和核酸合成中。此外，NADP / NADPH还是细胞色素P450系统和其他氧化酶/还原酶反应系统的耦合辅酶，例如硫氧蛋白还原酶/硫氧蛋白系统的辅酶。