2-amino-1-[1]naphthyl-propan-1-ol | 102994-22-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-amino-1-[1]naphthyl-propan-1-ol
• 英文别名: 2-Amino-1-naphthalen-1-ylpropan-1-ol
• CAS: 102994-22-9
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: JPXHVMVICUNHJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-1-[1]naphthyl-propan-1-ol 、 苯甲酰氯 在 sodium hydroxide 、 乙醚 作用下， 生成 N-(2-hydroxy-1-methyl-2-[1]naphthyl-ethyl)-benzamide
  参考文献：
  名称：

  SYNTHESIS OF ISOQUINOLINE DERIVATIVES

  摘要：

  DOI：

  10.1021/jo01156a018
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 乙醇 、 钯 作用下， 生成 2-amino-1-[1]naphthyl-propan-1-ol
  参考文献：
  名称：

  Amino Alcohols. X. Ring Substituted Propadrins

  摘要：

  DOI：

  10.1021/ja01309a039

文献信息

• Method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes which are used in asymmetric reduction reactions
  申请人：Burgos Alain

  公开号：US20070055068A1

  公开（公告）日：2007-03-08

  A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.

  一种用于原位制备从氧杂硼烷硼酸盐复合物中衍生的手性化合物的方法，其中将金属硼氢化物、路易斯碱和无机酸酯混合，然后加入手性活性氨基醇和可选的卤化物。所得化合物是一种复合物，可用作不对称还原反应中的催化剂。通过将待还原物质，特别是原始手性酮或醚肟加入以合成手性醇或手性胺来执行反应。
• An optically active borane complex and a method for producing an optically active alcohol derivative by the use thereof
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0171175A1

  公开（公告）日：1986-02-12

  An optically active borane complex represented by the general formula, wherein R1 represents an aryl group, R2 represents an alkyl group and a mark * means an asymmetric carbon, is capable of producing optically active alcohol derivatives by the reduction of prochiral ketones with the borane complex. The optically active alcohol derivative is useful for fungicides, herbicides or plant growth regulators.

  由通式表示的光学活性硼烷络合物、 其中 R1 代表芳基，R2 代表烷基，标记 * 表示不对称碳，通过用硼烷络合物还原原手性酮，可生产出光学活性醇衍生物。光学活性醇衍生物可用于杀真菌剂、除草剂或植物生长调节剂。
• Process for producing optically active alcohol
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0381434A1

  公开（公告）日：1990-08-08

  A process for producing an optically active alcohol of the formula [R⁴ and R⁵ are different and each is a lower alkyl group, an aryl group, and aralkyl group or a 2-substituted-1-­triazoleethylene group represented by the general formula (III) (R⁶ is a halogen- or haloalkyl-substituted or unsubstituted phenyl group or a cycloalkyl group)] comprises allowing (A) an optically active amino alcohol represented by the general formula (I) (R¹ is an aryl group, R² is a lower alkyl group, R³ is a hydrogen atom or a lower alkyl group, and the carbon atoms having a mark * are each an asymmetric carbon atom) and an acid, or a salt of the optically active amino alcohol (I) and an acid, (B) a metal borohydride, and (C) at least one of water, sulfides, cyclic ethers and ethers of mono alcohols to react with a prochiral ketone represented by the general formula (II) [R⁴ and R⁵ are as defined above].

  一种生产式如下的光学活性醇的工艺 [R⁴和R⁵是不同的，且各自是由通式(III)代表的低级烷基、芳基、芳烷基或 2-取代的-1-三唑乙烯基团 (R⁶为卤素或卤代烷基取代或未取代的苯基或环烷基）]包括允许 (A) 由通式(I)代表的光学活性氨基醇 (R¹为芳基，R²为低级烷基，R³为氢原子或低级烷基，带有标记*的碳原子均为不对称碳原子)和酸，或光学活性氨基醇(I)和酸的盐、 (B) 金属硼氢化物，以及 (C) 水、硫化物、环醚和单醇醚中的至少一种 与下列物质反应 与通式 (II) 所代表的手性酮反应 [R⁴ 和 R⁵ 如上定义]。
• Process for producing optically active carbinols
  申请人：SUMIKA FINE CHEMICALS Company, Limited

  公开号：EP0713848A1

  公开（公告）日：1996-05-29

  The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active α-phenyl-substituted-β-amino alcohols of the formula (3) or optically active α-non-substituted-β-amino alcohols of the formula (4). The present invention further relates to a process for producing optically active carbinols, comprising reacting with an unsymmetric ketone, an asymmetric reducing agent obtained from optically active β-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid.

  本发明涉及一种生产光学活性的式(1)卤代甲基苯基甲醇的工艺，包括使用从硼烷和光学活性的式(3)α-苯基取代-β-氨基醇或光学活性的式(4)α-非取代-β-氨基醇中得到的不对称还原剂还原式(2)卤代甲基苯基酮。 本发明还涉及一种生产光学活性烷醇的工艺，包括与不对称酮、从式（5）光学活性β-氨基醇中得到的不对称还原剂、金属硼氢化物和路易斯酸或低级二烷基硫酸反应。
• Processes for preparing optically active alcohols and optically active amines
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0736509A2

  公开（公告）日：1996-10-09

  A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active β-aminoalcohol and a boron hydride; or obtained from the optically active β-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active β-aminoalcohol and a boron hydride, or obtained from said optically active β-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

  一种制备光学活性醇的工艺，其方法是将对应于光学活性醇的手性酮和酸与(1)选自以下组别的含硼化合物和(2)选自以下组别的含硼化合物的混合物反应：①从光学活性β-氨基醇和氢化硼中得到的硼烷化合物；或从光学活性β-氨基醇、金属硼氢化物和酸中得到的硼烷化合物；②光学活性噁唑硼烷和(2)金属硼氢化物；以及一种制备光学活性胺的工艺，其方法是使肟衍生物和酸与(1)一种含硼化合物与(2)一种金属硼氢化物的混合物反应，该含硼化合物选自以下组别：(1)一种硼烷化合物，该硼烷化合物由光学活性β-氨基醇和硼氢化物得到，或由所述光学活性β-氨基醇、金属硼氢化物和酸得到；以及(2)一种光学活性噁唑硼烷和(2)一种金属硼氢化物。