1-fluoro-N-[(3R,4S)-hydroxytetrahydropyran-4-yl]-4-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]naphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-fluoro-N-[(3R,4S)-hydroxytetrahydropyran-4-yl]-4-[[6-(1-methylpyrazol-4-yl)-3-pyridyl]methyl]naphthalene-2-carboxamide
• 英文别名: 1-fluoro-N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-4-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)-2-naphthamide；1-fluoro-N-((3RS,4SR)-3-hydroxytetrahydro-2H-pyran-4-yl)-4-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)-2-naphthamide；1-fluoro-N-[(3R,4S)-3-hydroxyoxan-4-yl]-4-[[6-(1-methylpyrazol-4-yl)pyridin-3-yl]methyl]naphthalene-2-carboxamide
• 化学式: C₂₆H₂₅FN₄O₃
• 分子量: 460.508
• InChiKey: PQZBCCGOIMNBLV-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  89.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• FLOURO-NAPHTHYL DERIVATIVES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20160326144A1

  公开（公告）日：2016-11-10

  The present invention relates to compounds of formula wherein R 1 is C 4-6 -cycloalkyl or C 4-6 -heterocycloalkyl, which are optionally substituted by one or two substituents, selected from hydroxy or lower alkyl; A is phenyl, pyridinyl or piperidinyl; R 2 is hydrogen, halogen, lower alkyl, cyano, C 4-6 -cycloalkyl, lower alkoxy, lower alkoxy substituted by halogen, or is a five- or six-membered heteroaryl, optionally substituted by lower alkyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment or prophylaxis of Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders.

  本发明涉及通式化合物，其中R1为C4-6环烷基或C4-6杂环烷基，其任选地被一个或两个选自羟基或低级烷基的取代基取代；A为苯基、吡啶基或哌啶基；R2为氢、卤素、低级烷基、氰基、C4-6环烷基、低级烷氧基、被卤素取代的低级烷氧基，或为任选地被低级烷基取代的五元或六元杂芳基；n为1或2；或涉及药学上可接受的酸加成盐、外消旋混合物或其相应的对映体和/或光学异构体。这些化合物可用于治疗或预防阿尔茨海默病、认知障碍、精神分裂症、疼痛或睡眠障碍。
• US9708302B2
  申请人：——

  公开号：US9708302B2

  公开（公告）日：2017-07-18