(5R)-4-(cyclohexylmethyl)-1-[(2R)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propan-2-ylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5R)-4-(cyclohexylmethyl)-1-[(2R)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propan-2-ylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dione
• 化学式: C₄₃H₅₅N₅O₅
• 分子量: 721.9
• InChiKey: RWNPDBWKKCTTOI-WIQNKZILSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  53
• 可旋转键数：
  12
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROM SCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES
  申请人：STC.UNM

  公开号：US20160320402A1

  公开（公告）日：2016-11-03

  The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
• US9310364B1
  申请人：——

  公开号：US9310364B1

  公开（公告）日：2016-04-12
• [EN] INHIBITORS OF FPR2, COMPOSITIONS AND USES THEREOF FOR MODULATING INFLUENZA VIRUS REPLICATION<br/>[FR] INHIBITEURS DE FPR2, COMPOSITIONS ET UTILISATIONS DE CEUX-CI POUR MODULER LA RÉPLICATION DU VIRUS DE LA GRIPPE
  申请人：UNIV D'AIX-MARSEILLE

  公开号：WO2017162704A1

  公开（公告）日：2017-09-28

  The present invention relates to the modulation of influenza virus replication. Inventors in particular herein provide FPR2 modulators as well as compositions, kits and uses thereof. Also herein described are methods for preventing and/or treating influenza infections and methods for producing a vaccine composition.