1,4-diglycolylpiperazine | 79491-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-diglycolylpiperazine
• 英文别名: 2-Hydroxy-1-[4-(2-hydroxyacetyl)piperazin-1-yl]ethanone
• CAS: 79491-89-7
• 化学式: C₈H₁₄N₂O₄
• 分子量: 202.21
• InChiKey: DWYXBYXEDJCWBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌嗪 、 2,2-二甲基-1,3-二氧戊环-4-酮 以 二氯甲烷 为溶剂， 以20%的产率得到1,4-diglycolylpiperazine
  参考文献：
  名称：

  Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides

  摘要：

  On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H(37)Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) P to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.022

文献信息

• Synthetic absorbable surgical devices of polyester amides and process for making them
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0030822A2

  公开（公告）日：1981-06-24

  A body-absorbable polymeric material for surgical implantation which is a condensation product of reacting a diamine with lactic or glycolic acid to form a diamidediol which is then reacted with a bischloroformate or a compound selected from the group consisting of dicarboxylic acids, methyl and ethyl esters of dicarboxylic acids, diacidchlorides, and anhydrides of a dicarboxylic acid. The polymeric material has a high degree of softness and flexibility and it is useful as synthetic absorbable surgical sutures.

  一种可被人体吸收的外科植入用聚合材料，它是二胺与乳酸或乙醇酸反应生成二亚硫酸的缩合产物，二亚硫酸再与双氯甲酸酯或选自二羧酸、二羧酸甲酯和乙酯、二酸氯化物和二羧酸酸酐组成的化合物反应生成。这种聚合物材料具有高度的柔软性和弹性，可用作合成可吸收手术缝合线。
• US3987181A
  申请人：——

  公开号：US3987181A

  公开（公告）日：1976-10-19
• US4197307A
  申请人：——

  公开号：US4197307A

  公开（公告）日：1980-04-08
• US4151298A
  申请人：——

  公开号：US4151298A

  公开（公告）日：1979-04-24
• US4153723A
  申请人：——

  公开号：US4153723A

  公开（公告）日：1979-05-08