5-amino-1,10-phenanthroline | 69380-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 5-amino-1,10-phenanthroline
• 英文别名: [1,10]phenanthrolin-4-ylamine；1,10-Phenanthrolin-4-amine
• CAS: 69380-48-9
• 化学式: C₁₂H₉N₃
• 分子量: 195.224
• InChiKey: MWSWMKBNGFFPQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• QUINAZOLINE DERIVATIVES AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICAITON OF TUMOR CELLS AND PREPARATION METHOD THEREOF
  申请人：Wang Fuyi

  公开号：US20130225811A1

  公开（公告）日：2013-08-29

  Quinazoline derivatives represented by general formula (1) and quinazoline complexes as protein kinase inhibitors, and their preparation methods are provided. Wherein, in general formula (1), at least one of R and R′ is a group containing an atom capable of coordinating with noble metals, m and n are either the same or different and are integers from 0 to 5. Said quinazoline complex as protein kinase inhibitor is formed by coordination compound containing noble metal and said quinazoline derivative ligand capable of coordinating with noble metal in the coordination compound. Used as tyrosine protein kinase inhibitors, Quinazoline derivatives and quinazoline complexes as protein kinase inhibitors provided by the present invention have exhibited good inhibitory effect on proliferation of various tumor cells including human breast cancer cells line (drug-resistant) MCF-7/A, human breast cancer cell line (sensitive) MCF-7/S, prostate cancer cell PC-3, keratinocytes Colo-16, human non-small cell lung cancer cell line A549, etc.

  通用公式（1）表示的喹唑啉衍生物和作为蛋白激酶抑制剂的喹唑啉配合物，以及它们的制备方法已提供。在通用公式（1）中，R和R′中至少一个是含有能够与贵金属配位的原子的基团，m和n可以相同也可以不同，是从0到5的整数。所述的作为蛋白激酶抑制剂的喹唑啉配合物是由含有贵金属的配合物和所述喹唑啉衍生物配体在配合物中能够与贵金属配位而形成的。作为酪氨酸蛋白激酶抑制剂使用，本发明提供的喹唑啉衍生物和作为蛋白激酶抑制剂的喹唑啉配合物在抑制包括人类乳腺癌细胞系（耐药性）MCF-7/A、人类乳腺癌细胞系（敏感性）MCF-7/S、前列腺癌细胞PC-3、角质细胞Colo-16、人类非小细胞肺癌细胞系A549等各种肿瘤细胞增殖方面表现出良好的抑制作用。
• QUINAZOLINE DERIVATIVE AND QUINAZOLINE COMPLEX PROTEIN KINASE INHIBITOR FOR INHIBITING MULTIPLICATION OF TUMOR CELLS AND PREPARATION METHOD THEREOF
  申请人：Institute Of Chemistry, Chinese Academy Of Sciences

  公开号：EP2634178A1

  公开（公告）日：2013-09-04

  Quinazoline derivatives represented by general formula (1) and quinazoline complexes as protein kinase inhibitors, and their preparation methods are provided. Wherein, in general formula (1), at least one of R and R' is a group containing an atom capable of coordinating with noble metals, m and n are either the same or different and are integers from 0 to 5. Said quinazoline complex as protein kinase inhibitor is formed by coordination compound containing noble metal and said quinazoline derivative ligand capable of coordinating with noble metal in the coordination compound. Used as tyrosine protein kinase inhibitors, Quinazoline derivatives and quinazoline complexes as protein kinase inhibitors provided by the present invention have exhibited good inhibitory effect on proliferation of various tumor cells including human breast cancer cells line (drug-resistant) MCF-7/A, human breast cancer cell line (sensitive) MCF-7/S, prostate cancer cell PC-3, keratinocytes Colo-16, human non-small cell lung cancer cell line A549, etc.

  提供了通式（1）代表的喹唑啉衍生物和作为蛋白激酶抑制剂的喹唑啉复合物及其制备方法。其中，在通式（1）中，R 和 R' 至少有一个是含有能与贵金属配位的原子的基团，m 和 n 可以相同或不同，并且是 0 至 5 的整数。作为蛋白激酶抑制剂的喹唑啉复合物是由含有贵金属的配位化合物和配位化合物中能与贵金属配位的喹唑啉衍生物配体形成的。作为酪氨酸蛋白激酶抑制剂，本发明提供的喹唑啉衍生物和喹唑啉复合物作为蛋白激酶抑制剂，对多种肿瘤细胞的增殖具有良好的抑制作用，包括人乳腺癌细胞株（耐药）MCF-7/A、人乳腺癌细胞株（敏感）MCF-7/S、前列腺癌细胞PC-3、角质形成细胞Colo-16、人非小细胞肺癌细胞株A549等。
• BENZOFURO[3',2':4,5]IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN ORGANIC LIGHT-EMITTING DEVICES (OLEDS)
  申请人：Samsung Display Co., Ltd.

  公开号：EP3693372A1

  公开（公告）日：2020-08-12

  The present invention relates to benzofuro[3',2':4,5]imidazo[1,2-a]pyridinederivatives and related compounds for use in organic light emitting devices (OLEDs). The OLED includes two electrodes and an organic layer disposed between the electrodes including a compound of the present invention. The compounds of the present invention are represented by Formula 1: in Formula 1, A11 is a C1-C60 heterocyclic group, A12 is a C5-C60 carbocyclic group or a C1-C60 heterocyclic group, X11 is O, X12 is C, X13 is selected from N, C, and C(R13), X14 is selected from N, C, and C(R14), and X13 and X14 are linked via a single bond or a double bond.

  本发明涉及用于有机发光器件（OLED）的苯并呋喃并[3',2':4,5]咪唑并[1,2-a]吡啶二衍生物及相关化合物。 OLED 包括两个电极和置于电极之间的有机层，有机层中包括本发明的化合物。 本发明的化合物由式 1 表示： 式 1 中，A11 是 C1-C60 杂环基团，A12 是 C5-C60 碳环基团或 C1-C60 杂环基团，X11 是 O，X12 是 C，X13 选自 N、C 和 C(R13)，X14 选自 N、C 和 C(R14)，X13 和 X14 通过单键或双键相连。
• Light-driven ion-pumping membrane systems
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11318424B2

  公开（公告）日：2022-05-03

  Dye-sensitized ion-pumping membranes and methods of preparing said membranes are described herein. A regenerative and reversible photoactive dye is covalently-bonded to membrane or separator for ion-pumping. The photoactive dye-functionalized membranes can be arranged with other ion-exchange membranes, which serve as selective contacts to afford photovoltaic action and therefore form a power-producing membrane that pumps ions for use in driving an ion-exchange or ion-transport process, such as desalination and electrodialysis.

  本文描述了染料敏化离子泵膜和制备所述膜的方法。可再生和可逆的光敏染料与膜或分离器共价键合，用于离子泵。光敏染料功能化膜可与其他离子交换膜排列在一起，作为选择性接触以提供光生伏打作用，从而形成一种泵送离子的发电膜，用于驱动离子交换或离子传输过程，如海水淡化和电渗析。
• LITHIUM ION BATTERIES
  申请人：GM Global Technology Operations LLC

  公开号：US20130071742A1

  公开（公告）日：2013-03-21

  A lithium ion battery includes a positive electrode, a negative electrode, and a microporous polymer separator soaked in an electrolyte solution. The microporous polymer separator is disposed between the positive electrode and the negative electrode. An ion exchange polymer material is any of i) incorporated as a binder in any of the positive electrode or the negative electrode, ii) deposited onto a surface of any of the positive electrode or the negative electrode, iii) incorporated into the microporous polymer separator, or iv) deposited onto a surface of the microporous polymer separator. Examples of methods for making the ion exchange polymer material for use in the lithium ion batteries are also disclosed herein.