2-[2-[2-Chloro-3-[[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2h-benzo[e]indol-2-ylidene]-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-1,1-dimethyl-3-(4-sulfobutyl)-1h-benzo[e]indolium hydroxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[2-[2-Chloro-3-[[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2h-benzo[e]indol-2-ylidene]-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-1,1-dimethyl-3-(4-sulfobutyl)-1h-benzo[e]indolium hydroxide
• 英文别名: 4-[(2Z)-2-[(2E)-2-[2-chloro-3-[(E)-2-[1,1-dimethyl-3-(4-sulfobutyl)benzo[e]indol-3-ium-2-yl]ethenyl]cyclohex-2-en-1-ylidene]ethylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonic acid;hydroxide
• 化学式: C46H53ClN2O7S2
• 分子量: 845.5
• InChiKey: UWLMDPSXKKUUGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.37
• 重原子数：
  58
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• MULTIVALENT TARGETING FLUORESCENT TRACER IN THE NEAR INFRARED RANGE FOR OPTICAL IMAGING
  申请人：FLUOPTICS

  公开号：US20180147303A1

  公开（公告）日：2018-05-31

  A fluorescent tracer for targeting tumors, comprises: at least one first fluorophore fluorescing in a range of wavelengths of between 700 and 1000 nm, a targeting assembly comprising at least two identical targeting molecules, and a cyclic oligopeptide: configured so as to define a mean plane defining a first upper face and a second lower face, comprising at least one first lysine amino acid residue on the second lower face, the targeting molecules being fixed to the first upper face of the mean plane, the fluorophore being fixed to the second lower face of the mean plane via a spacer arm connecting a carbon of the sequence of the at least three double bonds and the lysine amino acid residue of the oligopeptide.

  一种用于靶向肿瘤的荧光示踪剂，包括：至少一种在700至1000纳米波长范围内发光的第一荧光团，一个包含至少两个相同靶向分子的靶向组件，以及一个环状寡肽：被配置为定义一个平均平面，其中包括第一上表面和第二下表面，第二下表面上包括至少一个第一赖氨酸氨基酸残基，靶向分子被固定在平均平面的第一上表面上，荧光团通过连接至少三个双键序列的碳和寡肽的赖氨酸氨基酸残基之间的间隔臂被固定在平均平面的第二下表面上。
• Multivalent targeting fluorescent tracer in the near infrared range for optical imaging
  申请人：FLUOPTICS

  公开号：US10857242B2

  公开（公告）日：2020-12-08

  A fluorescent tracer for targeting tumors, comprises: at least one first fluorophore fluorescing in a range of wavelengths of between 700 and 1000 nm, a targeting assembly comprising at least two identical targeting molecules, and a cyclic oligopeptide: configured so as to define a mean plane defining a first upper face and a second lower face, comprising at least one first lysine amino acid residue on the second lower face, the targeting molecules being fixed to the first upper face of the mean plane, the fluorophore being fixed to the second lower face of the mean plane via a spacer arm connecting a carbon of the sequence of the at least three double bonds and the lysine amino acid residue of the oligopeptide.

  一种用于靶向肿瘤的荧光示踪剂，包括：至少一种在700至1000纳米波长范围内发出荧光的第一荧光团，由至少两个相同的靶向分子和环状寡肽组成的靶向组件：配置成限定第一上表面和第二下表面的平均平面，包括第二下表面上的至少一个第一赖氨酸氨基酸残基，靶向分子固定在平均平面的第一上表面上，荧光团通过连接至少三个双键序列的碳和寡肽的赖氨酸氨基酸残基的间隔臂固定在平均平面的第二下表面上。
• COMPOSITIONS AND METHODS FOR CREATING ELECTRONIC CIRCUITRY
  申请人：LEE YUEH-LING

  公开号：US20100009173A1

  公开（公告）日：2010-01-14

  The present invention is directed to non-lithographic patterning by laser (or similar-type energy beam) ablation, where the ablation system ultimately results in circuitry features that are relative free from debris induced over-plating defects (debris relating to the ablation process) and fully additive plating induced over-plating defects. Compositions of the invention include a circuit board precursor having an insulating substrate and a cover layer. The insulating substrate is made from a dielectric material and also a metal oxide activatable filler. The cover layer can be sacrificial or non-sacrificial and is used to remediate unwanted debris arising from the ablation process.
• SYNTHESIS AND CHARACTERIZATION OF NEAR IR FLUORESCENT MAGNETIC AND NON-MAGNETIC ALBUMIN NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
  申请人：Margel Shlomo

  公开号：US20130030282A1

  公开（公告）日：2013-01-31

  The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.
• DYE-STABILIZED NANOPARTICLES AND METHODS OF THEIR MANUFACTURE AND THERAPEUTIC USE
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US20200237670A1

  公开（公告）日：2020-07-30

  Described herein are nanoparticles which are largely made of (e.g., 90 wt. %) hydrophobic drugs and are stabilized by water soluble dyes. The nanoparticles can range in size from 30 nm to 150 nm and have highly negative surface charge (e.g., −55 mV). These nanoparticles are highly soluble in water, stable for days in PBS buffer and can be easily lyophilzed and reconstituted in water. Using quantitative self-assembly prediction calculations, topochemical molecular descriptors were identified and validated as highly predictive indicators of nano-assembly, nanoparticle size, and drug loading. The resulting nanoparticles selectively targeted kinase inhibitors to caveolin-1expressing human colon cancer and autochthonous liver cancer models to yield striking therapeutic effects while avoiding pERK inhibition in healthy skin. The nanoparticles exhibited remarkable anti-tumor efficacy in vitro and in vivo in models of hepatocellular carcinoma.