1-methyl-7-phenyl-1,2,3,4-tetrahydronaphthalene | 1350704-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-methyl-7-phenyl-1,2,3,4-tetrahydronaphthalene
• CAS: 1350704-33-4
• 化学式: C₁₇H₁₈
• 分子量: 222.33
• InChiKey: BPOXLJAILYKDST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-([1,1'-biphenyl]-4-yl)pentane-1,4-dione 在 三乙基硅烷 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到1-methyl-7-phenyl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane

  摘要：

  A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1,4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium(IV) chloride catalyzed cyclization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.054

文献信息

• A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane
  作者：Gang Li、Qiong Xiao、Chun Li、Xiaojian Wang、Dali Yin

  DOI：10.1016/j.tetlet.2011.10.054

  日期：2011.12

  A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1,4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium(IV) chloride catalyzed cyclization. (C) 2011 Elsevier Ltd. All rights reserved.