3-(2-phenylethyl)-1-methylglutarimide | 147767-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(2-phenylethyl)-1-methylglutarimide
• 英文别名: 1-Methyl-3-(2-phenylethyl)piperidine-2,6-dione；1-methyl-3-(2-phenylethyl)piperidine-2,6-dione
• CAS: 147767-28-0
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: LKZLTMVGTQIZHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-phenylethyl)-1-methylglutarimide 在 劳森试剂 作用下， 以33%的产率得到1-Methyl-3-(2-phenylethyl)piperidine-2,6-dithione
  参考文献：
  名称：

  Photoreaction of 1- and 3-Aralkyl Alicyclic Thioimides: Facile Syntheses of Various Azabicycloalkanes via Norrish Type II Process

  摘要：

  Photolysis of the 1-(omega-aralkyl)cyclic thioimides (1b,e,g,h) gave a pair of stereoisomers of 1-azabicycloalkanes (2, 3) in moderate yields. Similarly, in 3-(omega-phenylalkyl)cyclic thioimides (5a-e), a pair of stereoisomers of 2-azabicycloalkanes (6, 7) were obtained.

  DOI：

  10.3987/com-92-6141
• 作为产物：
  描述：

  1-甲基哌啶-2,6-二酮 、 乙基溴苯 在 sodium amide 作用下， 生成 3-(2-phenylethyl)-1-methylglutarimide
  参考文献：
  名称：

  Photoreaction of 1- and 3-Aralkyl Alicyclic Thioimides: Facile Syntheses of Various Azabicycloalkanes via Norrish Type II Process

  摘要：

  Photolysis of the 1-(omega-aralkyl)cyclic thioimides (1b,e,g,h) gave a pair of stereoisomers of 1-azabicycloalkanes (2, 3) in moderate yields. Similarly, in 3-(omega-phenylalkyl)cyclic thioimides (5a-e), a pair of stereoisomers of 2-azabicycloalkanes (6, 7) were obtained.

  DOI：

  10.3987/com-92-6141

文献信息

• Photoreaction of 1- and 3-Aralkyl Alicyclic Thioimides: Facile Syntheses of Various Azabicycloalkanes via Norrish Type II Process
  作者：Kazuaki Oda、Yuichi Fukuzawa、Kosei Ohno、Minoru Machida、Yuichi Kanaoka

  DOI：10.3987/com-92-6141

  日期：——

  Photolysis of the 1-(omega-aralkyl)cyclic thioimides (1b,e,g,h) gave a pair of stereoisomers of 1-azabicycloalkanes (2, 3) in moderate yields. Similarly, in 3-(omega-phenylalkyl)cyclic thioimides (5a-e), a pair of stereoisomers of 2-azabicycloalkanes (6, 7) were obtained.