dimethyl-(2-[1]naphthyloxy-ethyl)-amine | 50882-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dimethyl-(2-[1]naphthyloxy-ethyl)-amine
• 英文别名: 2-Dimethylamino-1-(naphthyl-(1)-oxy)-aethan；1-(2-Dimethylamino-aethoxy)-naphthalin；Dimethyl-(2-[1]naphthyloxy-aethyl)-amin；Dimethyl-[2-(naphthalen-1-yloxy)-ethyl]-amine；N,N-dimethyl-2-naphthalen-1-yloxyethanamine
• CAS: 50882-70-7
• 化学式: C₁₄H₁₇NO
• mdl: MFCD04275573
• 分子量: 215.295
• InChiKey: VWPBKUKQUUEARZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dimethyl-(2-[1]naphthyloxy-ethyl)-amine 在 碘甲烷 作用下， 生成 trimethyl-(2-[1]naphthyloxy-ethyl)-ammonium; iodide
  参考文献：
  名称：

  THE SYNTHESIS OF SOME TERTIARY NAPHTHOXYETHYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01139a006
• 作为产物：
  描述：

  萘酚 、 2-氯-N,N-二甲基乙胺 在 sodium hydroxide 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 dimethyl-(2-[1]naphthyloxy-ethyl)-amine
  参考文献：
  名称：

  Heterocyclic Amplifiers of Phleomycin .X. Derivatives of Diazine Mono-Thiol and Di-Thiol

  摘要：

  制备了一系列带有苯基取代基的吡嗪硫醇和嘧啶硫醇，并将其转化为氨基甲酰甲硫基、2-二甲基氨基乙硫基和 2-氨基乙硫基衍生物。吡嗪-2,3-和-2,6-二硫醇的类似衍生物也是与 N,N-二甲基-2-（1′- 和 2′-萘氧基）乙胺一起制备的。作为夫来霉素的放大剂，这些化合物显示出中等的二至三星级活性。

  DOI：

  10.1071/ch9860069

文献信息

• Cross-linked polymer
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0856539A1

  公开（公告）日：1998-08-05

  A cross-linked polymer containing, in its molecule, recurring units represented by the following formula (1), and having biodegradability and high water-absorbency: wherein R1 is a pendant group having at least one functional group selected from the group consisting of acidic groups and salts thereof, a glycino group and salts thereof, cationic groups and betaine groups; X1 is NH, NR1', R1' being an alkyl, aralkyl or aryl group, O or S; and n1 is 1 or 2.

  一种交联聚合物，其分子中含有下式(1)所代表的循环单元，并具有生物降解性和高吸水性： 其中，R1 是具有至少一个官能团的悬垂基团，该官能团选自由酸性基团及其盐、甘氨酸基团及其盐、阳离子基团和甜菜碱基团组成的组；X1 是 NH、NR1'，R1' 是烷基、芳烷基或芳基、O 或 S；n1 是 1 或 2。
• Emptoz,G. et al., Chimica Therapeutica, 1969, vol. 4, p. 283 - 289
  作者：Emptoz,G. et al.

  DOI：——

  日期：——
• Ratouis,R.; Boissier,J.R., Bulletin de la Societe Chimique de France, 1966, p. 3823 - 3825
  作者：Ratouis,R.、Boissier,J.R.

  DOI：——

  日期：——
• ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE CHROMATOGRAPHY RESIN
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：US20200406232A1

  公开（公告）日：2020-12-31

  Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatography. The chromatography resins allow for efficient purification of target biomolecules (e.g., recombinant proteins, antibodies, antibody-drug conjugates, or antibody derivatives including, but not limited to, antibody fragments and antibody fusions) from a sample, and have been found to be useful in purifying monomeric target biomolecules from aggregate target biomolecules. In an embodiment, the chromatography resins are useful for separating antibodies from one or more components (e.g., contaminants) in the sample.
• ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE CHROMATOGRAPHY RESINS
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：US20210069692A1

  公开（公告）日：2021-03-11

  Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.