9-Ethyl-9-methyl-1,2,3,4,6,7,8,9a-octahydroquinolizine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 9-Ethyl-9-methyl-1,2,3,4,6,7,8,9a-octahydroquinolizine
• 英文别名: 9-ethyl-9-methyl-1,2,3,4,6,7,8,9a-octahydroquinolizine
• 化学式: C₁₂H₂₃N
• 分子量: 181.32
• InChiKey: IUXANVCRNGJBFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] THIENOPYRIDINE INHIBITORS OF RIPK2<br/>[FR] INHIBITEURS THIÉNOPYRIDINE DE RIPK2
  申请人：CELGENE CORP

  公开号：WO2020132384A1

  公开（公告）日：2020-06-25

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. The present application provides technologies useful for inhibiting RIPK2. In some embodiments, provided technologies are useful for, among other things, treating and/or preventing inflammatory disorders such as inflammatory bowel disease. Among other things, the present application provides compositions comprising a compound reported herein (e.g., a compound of formula I, I', II, ΙI', III, III', IV, and/or IV'), or a pharmaceutically acceptable salt or derivative thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.