N-[[5-[(4-chlorophenyl)sulfamoyl]-2-hydroxyphenyl]carbamothioyl]naphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[[5-[(4-chlorophenyl)sulfamoyl]-2-hydroxyphenyl]carbamothioyl]naphthalene-2-carboxamide
• 化学式: C₂₄H₁₈ClN₃O₄S₂
• 分子量: 512.0
• InChiKey: DOFYHFZVJVPTHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  148
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Phosphatidylcholine Transfer Protein Inhibitors
  申请人：Cohen David

  公开号：US20120264756A1

  公开（公告）日：2012-10-18

  This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.
• US9126938B2
  申请人：——

  公开号：US9126938B2

  公开（公告）日：2015-09-08