N-[[3-[(2-bromo-5-methylphenyl)sulfamoyl]phenyl]carbamothioyl]naphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[[3-[(2-bromo-5-methylphenyl)sulfamoyl]phenyl]carbamothioyl]naphthalene-2-carboxamide
• 化学式: C₂₅H₂₀BrN₃O₃S₂
• 分子量: 554.5
• InChiKey: JTQCANYOPDOTQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  128
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Phosphatidylcholine Transfer Protein Inhibitors
  申请人：Cohen David

  公开号：US20120264756A1

  公开（公告）日：2012-10-18

  This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.
• US9126938B2
  申请人：——

  公开号：US9126938B2

  公开（公告）日：2015-09-08
• [EN] PHOSPHATIDYLCHOLINE TRANSFER PROTEIN INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE DE TRANSFERT DE LA PHOSPHATIDYLCHOLINE
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2011022393A2

  公开（公告）日：2011-02-24

  This invention relates to compounds of Formulas I, II, and III, and their use as inhibitors of phosphatidylcholine transfer protein (PC-TP). The invention further relates to pharmaceutical compositions and methods of treatment of disorders related to the inhibition of PC-TP using the compounds of Formulas I, II, and III. Such disorders include obesity and disorders associated with obesity.