methyl (Z)-2-cyano-3-naphthalen-1-ylprop-2-enoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl (Z)-2-cyano-3-naphthalen-1-ylprop-2-enoate
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.25
• InChiKey: SKXSARWCVFRQRV-LCYFTJDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters
  申请人：Liu Weiguo

  公开号：US20050277784A1

  公开（公告）日：2005-12-15

  The present invention provides processes for the preparation of compounds of Formula III that are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases.

  本发明提供了一种用于制备公式III化合物的方法，这些化合物在制备用于治疗炎症性疾病的药物中非常有用。
• Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters
  申请人：Liu Weiguo

  公开号：US20050277783A1

  公开（公告）日：2005-12-15

  The present invention provides processes for the preparation of compounds of Formula I, which are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases. The compounds of Formula I are also useful as pharmaceuticals.

  本发明提供了一种制备I式化合物的方法，该方法有助于制备用于治疗炎症性疾病的药物。I式化合物也可用作药物。
• US7476752B2
  申请人：——

  公开号：US7476752B2

  公开（公告）日：2009-01-13
• [EN] PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-3-PHENYL-PROPIONIC ACID ALKYL OR BENZYL ESTERS<br/>[FR] PROCEDES POUR LA PREPARATION D'ESTERS D'ALKYLE OU DE BENZYLE DE L'ACIDE 2-CYANO-3-NAPHTHALENE-1-YL-3-PHENYL-PROPIONIQUE
  申请人：WYETH CORP

  公开号：WO2005123663A1

  公开（公告）日：2005-12-29

  The present invention provides processes for the preparation of compounds of Formula (1), which are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases. The compounds of Formula (I) are also useful as pharmaceuticals.