N-(4-methylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide | 304659-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: N-(4-methylphenyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide
• 英文别名: N-(4-methylphenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
• CAS: 304659-09-4
• 化学式: C₁₇H₁₈N₂O
• mdl: MFCD01961178
• 分子量: 266.34
• InChiKey: NNKREQOEPILALQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• NAMPT INHIBITORS
  申请人：Curtin Michael L.

  公开号：US20120122924A1

  公开（公告）日：2012-05-17

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

  揭示了抑制NAMPT活性的化合物，包含这些化合物的组合物以及治疗NAMPT表达疾病的方法。
• NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF
  申请人：Tachdjian Catherine

  公开号：US20090111834A1

  公开（公告）日：2009-04-30

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及发现某些非自然产生的、非肽酰胺化合物和酰胺衍生物，例如草酰胺、尿素和丙烯酰胺，是有用的风味或口感调节剂，例如风味或调味剂和风味或口感增强剂，更具体地，是咸味（单钠谷氨酸的“鲜味”）或甜味调节剂，咸味或甜味调味剂和咸味或甜味增强剂，用于食品、饮料和其他可食用或口服药物或组合物。
• T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
  申请人：SENOMYX, INC.

  公开号：US10352929B2

  公开（公告）日：2019-07-16

  The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

  本发明涉及与 T1R1/T1R3 或 T1R2/T1R3 受体或其片段或亚单位特异性结合的化合物。本发明还涉及在测定中使用包含 T1R1/T1R3 和 T1R2/T1R3 的异源同源体和嵌合味觉受体，以鉴定分别对鲜味刺激和甜味刺激做出反应的化合物。此外，本发明还涉及在组成型或诱导型条件下稳定或瞬时共表达 T1R1 和 T1R3 或 T1R2 和 T1R3 组合的细胞系的组成。本发明还提供了在基于细胞的检测中使用这些细胞系鉴定鲜味和甜味调节化合物的方法，特别是通过荧光成像检测受体活性的高通量筛选检测方法。
• Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
  申请人：Firmenich Incorporated

  公开号：US10557845B2

  公开（公告）日：2020-02-11

  The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

  本发明涉及发现某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺、脲和丙烯酰胺，是有用的风味或口味调节剂，例如香料或调味剂以及风味或口味增强剂、尤其是咸味（谷氨酸钠的 "鲜味"）或甜味调节剂--咸味或甜味调味剂和咸味或甜味增味剂，可用于食品、饮料和其他可食用或口服的医药产品或组合物。
• T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
  申请人：Li Xiaodong

  公开号：US20070104709A1

  公开（公告）日：2007-05-10

  The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.