(2S)-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2S)-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.2
• InChiKey: GIIOASILGOFVPI-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• INHIBITOR OF APOPTOSIS PROTEIN (IAP) ANTAGONISTS
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20150307499A1

  公开（公告）日：2015-10-29

  Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供的是调节细胞凋亡抑制蛋白(IAPs)活性的化合物，包含这些化合物的组合物，以及使用这些化合物和组合物的方法。
• NEW COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING, AND SYNTHESIS, NANO-STRUCTURE AND USE THEREOF
  申请人：Shanghai Lumosa Therapeutics Co., Ltd.

  公开号：EP3006454A1

  公开（公告）日：2016-04-13

  The present invention relates to a compound simultaneously having triple activities of thrombolysis, antithrombosis and free radical scavenging, as well as the preparation method, composition, and applications thereof. The compound is represented by the formula I shown below: wherein the definitions of T, Q, R1 and R2 are described herein.The compound of the present invention simultaneously has triple functions of thrombolysis, free radical scavenging and thrombus-targeting/antithrombosis. The present invention also relates to a pharmaceutical composition comprising the compound, and a preparation method and a nanostrutucre of the compound.

  本发明涉及一种同时具有溶栓、抗血栓和清除自由基三重活性的化合物及其制备方法、组成和应用。该化合物由下式 I 表示： 本发明的化合物同时具有溶栓、清除自由基和血栓靶向/抗血栓形成三重功能。本发明还涉及一种包含该化合物的药物组合物，以及该化合物的制备方法和纳米药物。
• Inhibitor of Apoptosis Protein (IAP) Antagonists
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170081362A1

  公开（公告）日：2017-03-23

  Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
• Use of Inhibitor of Apoptosis Protein (IAP) Antagonists in HIV Therapy
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170196879A1

  公开（公告）日：2017-07-13

  Provided herein is the use of compounds that modulate the activity of inhibitor of apoptosis proteins (1APs), alone or in combination with other therapeutic agents, in the treatment of human immunodeficiency virus (HIV). Described herein is the use of IAP antagonists in the treatment of human immunodeficiency virus (HIV) in a mammal, alone or in combination with other therapeutic agents used in HIV therapy. In one aspect, provided herein is a method of treating human immunodeficiency virus (HIV) in an individual in need thereof comprising administering a therapeutically effective amount of at least one inhibitor of apoptosis proteins (IAP) antagonist.
• US9546174B2
  申请人：——

  公开号：US9546174B2

  公开（公告）日：2017-01-17