(+/-)-3-(dibenzofuran-2-yloxy)-1-azabicyclo[2.2.2]octane fumaric acid salt | 663193-09-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (+/-)-3-(dibenzofuran-2-yloxy)-1-azabicyclo[2.2.2]octane fumaric acid salt
• 英文别名: (+/-)-3-(Dibenzofuran-2-yloxy)-1-azabicvclo[2.2.2]octane fumaric acid salt；(E)-but-2-enedioic acid;3-dibenzofuran-2-yloxy-1-azabicyclo[2.2.2]octane
• CAS: 663193-09-7
• 化学式: C₄H₄O₄*C₁₉H₁₉NO₂
• 分子量: 409.439
• InChiKey: TYEWAAMGGWYJNY-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.77
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (+/-)-3-(dibenzofuran-2-yloxy)-1-azabicyclo[2.2.2]octane 、 富马酸 以 甲醇 、 乙醚 为溶剂， 生成 (+/-)-3-(dibenzofuran-2-yloxy)-1-azabicyclo[2.2.2]octane fumaric acid salt
  参考文献：
  名称：

  [EN] NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
  [FR] NOUVEAUX DERIVES QUINUCLIDINIQUES ET LEUR UTILISATION

  摘要：

  该发明涉及新型喹诺啉衍生物及其作为药物的用途。由于其药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等疾病或疾病有用。

  公开号：

  WO2004016608A1

文献信息

• Novel quinuclidine derivatives and their use
  申请人：Peters Dan

  公开号：US20050245567A1

  公开（公告）日：2005-11-03

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的莨菪碱衍生物及其作为药物的使用。由于它们的药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或疾患、与平滑肌收缩有关的疾病或疾患、内分泌疾病或疾患、神经退行性疾病或疾患、与炎症、疼痛有关的疾病或疾患以及因化学物质滥用终止而引起的戒断症状可能有用。
• Novel quinuclidine derivatives and their pharmaceutical use
  申请人：Peters Dan

  公开号：US20060217415A1

  公开（公告）日：2006-09-28

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的用途。由于它们的药理特性，本发明化合物可用于治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或障碍，与平滑肌收缩有关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛以及由于滥用化学物质而引起的戒断症状等多种疾病或障碍的治疗。
• NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
  申请人：PETERS Dan

  公开号：US20090005390A1

  公开（公告）日：2009-01-01

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的用途。由于它们的药理特性，本发明中的化合物可能对多种与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱，内分泌疾病或紊乱，神经退行性疾病或紊乱，炎症、疼痛以及由于滥用化学物质而导致的戒断症状等疾病或紊乱有用。
• Quinuclidine derivatives and their pharmaceutical use
  申请人：Neurosearch A/S

  公开号：US07750022B2

  公开（公告）日：2010-07-06

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的应用。由于其药理特性，本发明的化合物可用于治疗与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症、疼痛以及由于滥用化学物质而导致的戒断症状等多种疾病或障碍的治疗。
• NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
  申请人：NeuroSearch A/S

  公开号：EP1656375B1

  公开（公告）日：2011-01-19