8-氯-1-辛炔 | 24088-97-9

• 分子结构分类: 有机化合物 - 乙炔化物
• 中文名称: 8-氯-1-辛炔
• 英文名称: 8-chloro-oct-1-yne
• 英文别名: 8-chloro-1-octyne；1-chloro-7-octyne；1-Octyne, 8-chloro-；8-chlorooct-1-yne
• CAS: 24088-97-9
• 化学式: C₈H₁₃Cl
• 分子量: 144.644
• InChiKey: HQHUHJPIECZMCX-UHFFFAOYSA-N

物化性质

• 沸点：
  73-76 °C(Press: 10 Torr)
• 密度：
  0.928±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903299090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 8-Chlorooct-1-yne
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 8-Chlorooct-1-yne
CAS number: 24088-97-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H13Cl
Molecular weight: 144.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  8-氯-1-辛炔 在 sodium tetrahydroborate 、 氢气 、 nickel diacetate 、 zinc(II) oxide 作用下， 以 甲醇 为溶剂， 反应 11.0h， 以82.5%的产率得到1-氯辛烷
  参考文献：
  名称：

  METHOD FOR PRODUCING REDUCED HALIDE COMPOUND HAVING UNDERGONE REDUCTION OF CARBON-CARBON UNSATURATED BOND

  摘要：

  一种卤化物化合物，其具有一个或多个碳-碳不饱和键，经催化还原而几乎不发生去卤反应，以产生一个减少的卤化物化合物，其中至少一个或多个不饱和键被还原。具体提供了一种生产减少的卤化物化合物的方法，包括以下步骤：在溶剂中反应镍化合物、锌化合物和硼氢化物化合物以获得还原催化剂；并在还原催化剂存在的情况下，将具有一个或多个碳-碳不饱和键的卤化物化合物进行催化还原，以减少至少一个或多个碳-碳不饱和键，从而获得减少的卤化物化合物。

  公开号：

  US20190322607A1
• 作为产物：
  描述：

  1,6-二氯己烷 在 氨 、 sodium iodide 作用下， 以 乙醚 为溶剂， 生成 8-氯-1-辛炔
  参考文献：
  名称：

  Synthesis of Unsaturated Fatty Acids. Positional Isomers of Linoleic Acid¹

  摘要：

  DOI：

  10.1021/jo01040a023

文献信息

• 1-Alkoximino-2-(.omega.-substituted alkyl)-2-cyclopentenes
  申请人：American Cyanamid Company

  公开号：US04006179A1

  公开（公告）日：1977-02-01

  This disclosure describes certain 1-alkoximino-2-(.omega.-substituted-alkyl)-2-cyclopentenes useful as intermediates for the preparation of homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid which have antimicrobial activity and prostaglandin-like hypotensive activity.

  本公开揭示了某些1-烷氧基亚胺基-2-(ω-取代烷基)-2-环戊烯，可用作9-氧代-13-反式前列腺酸及9-羟基-13-反式前列腺酸的同系物、类似物、同源物和衍生物的中间体，这些化合物具有抗微生物活性和类前列腺素降压活性。
• FATTY ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREFOR
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20190039989A1

  公开（公告）日：2019-02-07

  The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.

  本发明涉及一类脂肪酸化合物，其制备方法和用途。这些脂肪酸化合物具有式I的结构，具有激活APMK并抑制小鼠原代肝细胞中葡萄糖输出的能力。这些脂肪酸化合物可用于制备治疗肥胖或糖尿病的药物。
• Solventless and metal-free regioselective hydrofluorination of functionalized alkynes and allenes: an efficient protocol for the synthesis of <i>gem</i>-difluorides
  作者：Zhichao Lu、Bhvandip S. Bajwa、Shiwen Liu、Sheye Lee、Gerald B. Hammond、Bo Xu

  DOI：10.1039/c8gc03876g

  日期：——

  The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an easy workup.

  两种易于处理的高酸性液体 HF 络合物试剂 DMPU-12HF 和 KHSO 4 -13HF 的组合产生了高酸性氟化系统，该系统促进 HF 与广泛官能化的炔烃（包括炔烃系留药物或丙二烯）进行排他性马尔可夫尼科夫加成，以生产宝石二氟化物具有高原子经济性，并且易于后处理。
• Multimacrocyclic compounds. Part I. Novel triply bridged dibenzenoid cage compounds
  作者：A. J. Hubert

  DOI：10.1039/j39670000006

  日期：——

  Internal cyclotrimerisation of aromatic triynes on a Ziegler catalyst has given a series of compounds containing two aromatic rings joined by three polymethylene chains. Melting point alternation and spectral properties are similar to those of paracyclophanes.

  齐格勒催化剂上芳族三炔的内部环三聚反应产生了一系列化合物，这些化合物包含通过三个多亚甲基链连接的两个芳环。熔点的变化和光谱性质与对环烷的相似。
• Derivatives of 9-oxo-13-trans-prostenoic acid amides
  申请人：American Cyanamid Company

  公开号：US03981868A1

  公开（公告）日：1976-09-21

  This disclosure described homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenamide and of 9-hydroxy-13-trans-prostenamide, having antimicrobial activity and prostaglandin-like hypotensive activity.

  这份披露描述了9-氧基-13-反式前列胺酰胺和9-羟基-13-反式前列胺酰胺的同源物、类似物、同系物和衍生物，具有抗微生物活性和类前列腺素降压活性。