4-[2'-(5'-methyl)thienyl]dibenzofuran | 1241908-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-[2'-(5'-methyl)thienyl]dibenzofuran
• 英文别名: 4-(5-Methylthiophen-2-yl)dibenzofuran；4-(5-methylthiophen-2-yl)dibenzofuran
• CAS: 1241908-24-6
• 化学式: C₁₇H₁₂OS
• 分子量: 264.348
• InChiKey: LBCIMSCPXPKXAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  41.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-5-甲基噻吩 、 4-二苯并呋喃硼酸 在 sodium phosphate dodecahydrate 、 palladium 10% on activated carbon 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 以91%的产率得到4-[2'-(5'-methyl)thienyl]dibenzofuran
  参考文献：
  名称：

  Ligand-Free and Heterogeneous Palladium on Carbon-Catalyzed Hetero-Suzuki-Miyaura Cross-Coupling

  摘要：

  AbstractA ligand‐free and heterogeneous palladium on carbon (Pd/C)‐catalyzed hetero‐Suzuki–Miyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic‐alicyclic and heterocyclic‐heterocyclic biaryl derivatives in good to excellent yields. Furthermore, Pd/C could be reused. The time‐course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.

  DOI：

  10.1002/adsc.200900638

文献信息

• Ligand-Free and Heterogeneous Palladium on Carbon-Catalyzed Hetero-Suzuki-Miyaura Cross-Coupling
  作者：Yoshiaki Kitamura、Satoko Sako、Azusa Tsutsui、Yasunari Monguchi、Tomohiro Maegawa、Yukio Kitade、Hironao Sajiki

  DOI：10.1002/adsc.200900638

  日期：2010.3.8

  AbstractA ligand‐free and heterogeneous palladium on carbon (Pd/C)‐catalyzed hetero‐Suzuki–Miyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic‐alicyclic and heterocyclic‐heterocyclic biaryl derivatives in good to excellent yields. Furthermore, Pd/C could be reused. The time‐course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.