1-(5-Chloro-2-methylphenyl)-3-(5-hydroxy-1-naphthyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(5-Chloro-2-methylphenyl)-3-(5-hydroxy-1-naphthyl)urea
• 英文别名: 1-(5-chloro-2-methylphenyl)-3-(5-hydroxynaphthalen-1-yl)urea
• 化学式: C₁₈H₁₅ClN₂O₂
• 分子量: 326.8
• InChiKey: IPVKXGNHOBDCCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• hTRPV1 chemical agents
  申请人：UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US11339122B2

  公开（公告）日：2022-05-24

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.

  本研究公开了新型二苯基脲和苄基苯磺酰胺化合物，以及抑制 TRPV1 活性的方法和使用此类化合物治疗与瞬时受体电位香草素 1 型（TRPV1）有关的疼痛的方法。
• hTRPV1 CHEMICAL AGENTS
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20180215705A1

  公开（公告）日：2018-08-02

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.