N-(4-hydroxynaphthalen-1-yl)-2,5-dimethylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-hydroxynaphthalen-1-yl)-2,5-dimethylbenzenesulfonamide
• 化学式: C₁₈H₁₇NO₃S
• mdl: MFCD02216727
• 分子量: 327.4
• InChiKey: SEBVJYWOFMIHFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Modulation of Oxidative Stress and Amino Acid Metabolism for the Treatment or Prevention of Diseases and Disorders
  申请人：NEW YORK UNIVERSITY

  公开号：US20210085763A1

  公开（公告）日：2021-03-25

  The present invention relates methods for treating cancer by comprising administering to the subject an agent for reducing at least one NEAA, inhibiting the PPP pathway, inhibiting the sorbitol pathway, inhibiting heme biosynthesis, or any combination thereof. The invention also includes methods of treating cancer comprising detecting a tumor as having increased ROS administering to the subject an agent for reducing at least one NEAA, inhibiting the PPP pathway, inhibiting the sorbitol pathway or inhibiting heme biosynthesis, or any combination thereof.