The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I), wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
本发明涉及一种新的单环和双环环系统取代的碳核苷类似物,
化学式为(I),其中变量的含义如权利要求中所定义。根据本发明的化合物可用作PR
MT5
抑制剂。本发明还涉及包含所述化合物作为活性成分的药物组合物,以及将所述化合物用作药物的用途。