Synthesis of chiral cyclic amines via Ir-catalyzed enantioselective hydrogenation of cyclic imines
作者:Ying Zhang、Duanyang Kong、Rui Wang、Guohua Hou
DOI:10.1039/c7ob00442g
日期:——
A highly enantioselective hydrogenation of cyclic imines for synthesis of chiral cyclic amines has been realized. With the complex of iridium and (R,R)-f-spiroPhos as the catalyst, a range of cyclic 2-aryl imines were smoothly hydrogenated under mild conditions without any additive to provide the corresponding chiral cyclic amines with excellent enantioselectivities of up to 98% ee. Moreover, this
A novel convenient approach to the synthesis of 2-substituted analogs of ornithine and homolysine
作者:V. G. Nenajdenko、E. P. Zakurdaev、E. V. Prusov、E. S. Balenkova
DOI:10.1007/s11172-005-0204-9
日期:2004.12
A novel efficient method for the synthesis of earlier unknown 2-substituted analogs of ornithine and homolysine from substituted 5-aminopentyl- and 3-midopropylhydantoins (prepared from cyclic imines and amino and amido ketones) was developed. Hydrolysis of hydantoins with a solution of Ba(OH)2 gave the target amino acids in high yields.