[(2R)-1-methylpiperidin-2-yl]methanone | 852324-35-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [(2R)-1-methylpiperidin-2-yl]methanone
• 英文别名: (R)-1-Methylpiperidine-2-carbaldehyde；(2R)-1-methylpiperidine-2-carbaldehyde
• CAS: 852324-35-7
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: HBQKERHWQDYYEM-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(2R)-1-methylpiperidin-2-yl]methanone 、 N-[2-Amino-5-[(diethylamino)carbonyl]phenyl]-4-ethoxy-benzeneacetamide 在 borane pyridine complex 作用下， 以 DCE 、 溶剂黄146 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Novel benzimidazole derivatives as selective CB2 agonists

  摘要：

  The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (> 1000-fold) over the CB1 receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.073

文献信息

• DESACETOXYTUBULYSIN H AND ANALOGS THEREOF
  申请人：William Marsh Rice University

  公开号：EP3261443B1

  公开（公告）日：2021-04-28
• [EN] BINDING LIGAND LINKED DRUG DELIVERY CONJUGATES OF TUBULYSINS<br/>[FR] CONJUGUÉS D'ADMINISTRATION DE MÉDICAMENT LIÉS À UN LIGAND DE LIAISON DE TUBULYSINES
  申请人：ENDOCYTE INC

  公开号：WO2008112873A2

  公开（公告）日：2008-09-18

  [EN] Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.
  [FR] L'invention concerne des composés, compositions pharmaceutiques et procédés pour traiter des populations de cellules pathogènes. Les composés décrits ici comprennent des composés de tubulysines et des ligands de liaison à un récepteur de vitamine. Les conjugués comprennent également un liant bivalent pouvant être libéré.
• [EN] METHODS FOR TREATING CANCER USING COMBINATION THERAPIES<br/>[FR] MÉTHODES POUR TRAITER LE CANCER AU MOYEN DE POLYTHÉRAPIES
  申请人：ENDOCYTE INC

  公开号：WO2014085575A1

  公开（公告）日：2014-06-05

  Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc-inhibitor for the treatment of cancer or inflammation. Also described are invitro assays utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc- inhibitor.
• [EN] CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS<br/>[FR] CONJUGUÉS DE COMPOSÉS DE TUBULYSINE QUATERNISÉS
  申请人：SEATTLE GENETICS INC

  公开号：WO2017096311A1

  公开（公告）日：2017-06-08

  Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.