5-ethyl-[1,10]phenanthroline | 107919-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 5-ethyl-[1,10]phenanthroline
• 英文别名: 5-Aethyl-[1,10]phenanthrolin；5-Ethyl-1,10-phenanthroline
• CAS: 107919-99-3
• 化学式: C₁₄H₁₂N₂
• 分子量: 208.263
• InChiKey: CYBRLDVVGUZTAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-乙基-8-硝基喹啉 在 硫酸 、 砷酸、原砷酸 、 铂 作用下， 生成 5-ethyl-[1,10]phenanthroline
  参考文献：
  名称：

  Substituted 1,10-Phenanthrolines. X. Ethyl Derivatives¹

  摘要：

  DOI：

  10.1021/jo01355a011

文献信息

• Electronically Neutral Metal Complexes As Biological Labels
  申请人：RUBIPY SCIENTIFIC, INC.

  公开号：US20160146826A1

  公开（公告）日：2016-05-26

  The invention relates to electronically neutral metal complexes as luminescent labels. The positive charge of the metal ion in the complex is neutralized by the negatively charged groups that are covalently linked to the nitrogen-containing diimine ligands, such as 2,2-bipyridine, 1,10-phenanthroline and their derivatives. The electronic neutrality reduces the impact of the metal complexes on the biological and/or biochemical activities of the labeled biomolecules, while the intensity of luminescent emission under electrochemical excitation is enhanced. These luminescent metal complex labels are useful in bioanalytic methodology development, with luminescence as the signal modality, such as electrochemiluminescence.

  该发明涉及作为发光标记的电子中性金属配合物。该配合物中金属离子的正电荷被共价连接到含氮双亚胺配体（如2,2-联吡啶，1,10-邻菲啰啉及其衍生物）上的带负电荷基团中和。电子中性减少了金属配合物对标记生物分子的生物和/或生化活性的影响，同时在电化学激发下增强了发光发射的强度。这些发光金属配合物标记在生物分析方法学的发展中非常有用，发光作为信号模态，如电化学发光。
• [EN] RADIOLABELED COMPOUNDS TARGETING THE PROSTATE-SPECIFIC MEMBRANE ANTIGEN<br/>[FR] COMPOSÉS RADIOMARQUÉS CIBLANT L'ANTIGÈNE MEMBRANAIRE SPÉCIFIQUE DE LA PROSTATE
  申请人：PROVINCIAL HEALTH SERVICES AUTHORITY

  公开号：WO2020252598A1

  公开（公告）日：2020-12-24

  A compound comprising a prostate specific membrane antigen (PSMA)-targeting moiety of the following formula or of a salt or a solvate thereof. R0 is O or S. Each of R1a, R1b and R1c may be –CO2H, –SO2H, –SO3H, –PO2H, or –PO3H2, for example. R2 may be methylene or a derivative thereof, propylene or a derivative thereof, or a derivative of ethylene, optionally substituted. R3 is a linker. When the PSMA-targeting moiety is linked to a radiolabeling group, the compound may be used as an imaging agent or therapeutic agent for PSMA-expressing diseases/conditions.

  一种化合物，包括以下结构式或其盐或溶剂化合物的前列腺特异性膜抗原（PSMA）靶向基团。R0为O或S。R1a、R1b和R1c中的每一个可以是-CO2H、-SO2H、-SO3H、-PO2H或-PO3H2，例如。R2可以是亚甲基或其衍生物、丙烯基或其衍生物，或乙烯的衍生物，可选择性地取代。R3是一个连接基。当PSMA靶向基团与放射标记基团连接时，该化合物可用作PSMA表达疾病/病况的成像剂或治疗剂。
• LIGAND-FUNCTIONALIZED/AZO COMPOUNDS AND METHODS OF USE THEREOF
  申请人：HARRUNA I. Issifu

  公开号：US20070276104A1

  公开（公告）日：2007-11-29

  Described herein are ligand-functionalized/azo compounds and methods of use thereof.

  本文描述了配体功能化/偶氮化合物及其使用方法。
• COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3219714A1

  公开（公告）日：2017-09-20

  Compound and Organic Light-Emitting Device Comprising the Same A compound is represented by one of Formulae 1 and 2: Wherein the components of Formulae 1 and 2 are each independently defined as set forth in the present disclosure. An organic light-emitting device comprises at least one of the compound represented by one of Formulae 1 and 2.

  化合物及其有机发光器件 一种化合物由式 1 和 2 之一表示： 其中，式 1 和 2 的组分各自独立地定义如本公开所述。有机发光器件包括至少一种由式 1 和 2 之一表示的化合物。
• LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL
  申请人：Gee Kyle

  公开号：US20100330584A1

  公开（公告）日：2010-12-30

  Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (M c ), a reporter molecule and two or more lipophilic groups (G L ) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.