N,N-dimethyl-4-[(E)-2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-dimethyl-4-[(E)-2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]aniline
• 化学式: C25H27N2+
• 分子量: 355.5
• InChiKey: XMZLQIZBRAKDNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Compounds as fluorescent probes, synthesis and applications thereof
  申请人：Institute for Stem Cell Biology and Regenerative Medicine (inStem)

  公开号：US10808128B2

  公开（公告）日：2020-10-20

  The present disclosure relates to chemical dyes useful for staining and imaging of cells. In particular, the disclosure relates to compound of Formula I, method of preparation thereof, and it's use as a fluorescent probe for staining and/or imaging mitochondria in cells, tissues or animals, resulting in a range of applications including, but not limiting, to sensing local ordering or viscosity of mitochondria, tracking mitochondrial mobility, comparing & evaluating mitochondrial function, local ordering, microviscosity and dynamics. Said dyes have additional advantages including, but not limiting, to low toxicity, longer shelf-life, generate little or no reactive species upon long term light irradiation and do not perturb the functionality of the mitochondria in cells compared to prior art dyes.

  本公开涉及用于细胞染色和成像的化学染料。特别是，本公开涉及式 I 的化合物、其制备方法及其作为荧光探针对细胞、组织或动物中的线粒体进行染色和/或成像的用途，其应用范围包括（但不限于）感知线粒体的局部有序性或粘度、跟踪线粒体的流动性、比较和评估线粒体的功能、局部有序性、微粘度和动态性。与现有技术的染料相比，上述染料还具有其他优点，包括但不限于毒性低、保质期长、在长期光照射下几乎不产生反应性物质，以及不会扰乱细胞中线粒体的功能。