2-azaniumyl-2-naphthalen-2-ylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-azaniumyl-2-naphthalen-2-ylpropanoate
• 化学式: C13H13NO2
• 分子量: 215.25
• InChiKey: TWZOVALINORIBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Melanocortin receptor ligands
  申请人：Mazur Adam Wieslaw

  公开号：US20060106059A1

  公开（公告）日：2006-05-18

  Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A has the formula: W is a unit which preferable comprises D-(4-fluorophenyl)alanine, Y comprises at least one nitrogen heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.

  本发明涉及MC-3/MC-4受体配体，该配体具有以下公式：其中A具有以下公式：W是一个单元，它最好包含D-(4-氟苯基)丙氨酸，Y至少包含一个氮杂原子，Z包含一个芳香环烃环。本发明还涉及包含本发明的配体的制药组合物以及通过MC-3/MC-4受体介导的疾病的治疗方法。
• APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME
  申请人：SNU R&DB Foundation

  公开号：EP2484692A1

  公开（公告）日：2012-08-08

  The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-I mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphtilalanine has superior cholesterol efflux capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-I mimic peptides of the present invention can be used as Apo A-I mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.

  本发明涉及载脂蛋白A-1模拟肽，以及由其组成的治疗高脂血症和与高脂血症相关疾病的治疗剂。更具体地说，本发明的载脂蛋白 A-1 拟态肽是通过修改现有 4F 两性肽的亲水面或疏水面来生产载脂蛋白 A-I 拟态肽的，这种肽能与胆固醇酯特异性结合，使高密度脂蛋白含量增加、4F 疏水面上的苯丙氨酸被 2-萘丙氨酸取代的肽在胆固醇外流能力和对脂质的认知功能方面优于现有的 4F 肽。因此，本发明的载脂蛋白 A-I 拟态肽可用作载脂蛋白 A-I 拟态肽和治疗剂，用于治疗高脂血症和与高脂血症有关的疾病。
• Peptides and compounds that bind to a receptor
  申请人：MacDonald R. Brian

  公开号：US20060040866A1

  公开（公告）日：2006-02-23

  Peptides and compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.

  本研究公开了与血小板生成素受体（c-mpl 或 TPO-R）结合并激活该受体或以其他方式作为 TPO 激动剂的多肽和化合物。
• JPH08301896A
  申请人：——

  公开号：JPH08301896A

  公开（公告）日：1996-11-19