5,8-Dibromo-3,3-dimethyl-9-(2-methylprop-2-en-1-yl)-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 5,8-Dibromo-3,3-dimethyl-9-(2-methylprop-2-en-1-yl)-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalene
• 英文别名: 3,6-dibromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
• 化学式: C₁₇H₂₁Br₂N
• 分子量: 399.2
• InChiKey: LQZVTORZIAYQLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS
  申请人：PAGANO Patrick J.

  公开号：US20160083351A1

  公开（公告）日：2016-03-24

  Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein “ ” represents a single or double bond, R 1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R a is hydrogen, —CH 2 R 2 , R 3 , or —SO 2 R 4 ; R 2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 4 is lower aliphatic, or substituted or unsubstituted aryl; and R 5 is hydrogen, halogen, or lower aliphatic.
• US9796681B2
  申请人：——

  公开号：US9796681B2

  公开（公告）日：2017-10-24