1-hydroxy-2H-1,2,4-benzotriazin-3-amine | 5424-06-6

• 物质功能分类: 化学试剂 - 有机试剂 - 肼
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 1-hydroxy-2H-1,2,4-benzotriazin-3-amine
• CAS: 5424-06-6
• 化学式: C₇H₈N₄O
• 分子量: 164.16
• InChiKey: PMULJRKUMBNABR-UHFFFAOYSA-N

物化性质

• 熔点：
  271°C
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.9
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933699090

文献信息

• Induction of tumor hypoxia for cancer therapy
  申请人：Virginia Commonwealth University

  公开号：US10426779B2

  公开（公告）日：2019-10-01

  Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by to catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

  本文提供了增强缺氧激活生物还原剂杀死实体瘤内肿瘤细胞能力的方法和组合物。 在肿瘤内或含有肿瘤的区域内形成局部缺氧区域，从而增强局部区域内缺氧激活的生物还原剂（如替拉帕扎胺）的活化。 活化的缺氧活化生物还原剂通过催化肿瘤细胞内的 DNA 支架断裂，杀死缺氧区域内的肿瘤细胞。 由于生物还原剂的活性是局部的，因此可减少因全身使用生物还原剂而产生的副作用。
• INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY
  申请人：Lee Ruey-min

  公开号：US20120087913A1

  公开（公告）日：2012-04-12

  Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
• Induction of Tumor Hypoxia for Cancer Therapy
  申请人：Virginia Commonwealth University

  公开号：US20140065139A1

  公开（公告）日：2014-03-06

  Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
• US9649316B2
  申请人：——

  公开号：US9649316B2

  公开（公告）日：2017-05-16