1-(2-Hydroxy-1-naphthyl)-2-(4-sulfophenyl)hydrazinesulfonic acid | 5863-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-Hydroxy-1-naphthyl)-2-(4-sulfophenyl)hydrazinesulfonic acid
• 英文别名: 4-[2-(2-hydroxynaphthalen-1-yl)-2-sulfohydrazinyl]benzenesulfonic acid
• CAS: 5863-98-9
• 化学式: C₁₆H₁₄N₂O₇S₂
• 分子量: 410.4
• InChiKey: JTXLXNWLXPNUMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Cancer-related extracellular matrix signatures and related methods and products
  申请人：Massachusetts Institute of Technology

  公开号：US10024860B2

  公开（公告）日：2018-07-17

  Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyzes of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.

  本研究提供了用于鉴定癌症相关蛋白的蛋白质组学方法以及相关产品和试剂盒。癌症特异性蛋白是与癌症各方面相关的细胞外基质蛋白。本文提供了用于检测、诊断和治疗癌症以及监测癌症患者治疗进展的蛋白质面板或特征集，以及用于检测它们和通过与特定蛋白质结合将成像和/或治疗剂靶向到肿瘤的方法。这些蛋白质是通过对癌症患者的组织样本进行蛋白质组学分析确定的。在某些方面，这些蛋白质尤其适用于结肠癌患者。
• Methods of Inhibiting Poxvirus Growth
  申请人：Sefton Bartholomew M.

  公开号：US20080306031A1

  公开（公告）日：2008-12-11

  This disclosure ascribes new functions to derivatives of tetralin, anthraquinone, naphthylamine, tri-amino-pyrimidine, xanthen-3-one, and/or cinnamic acid (including, for example, NSC270718R, NSC117285R, NSC170008Y, NSC306711P, NSC119913X, NSC119915Z, NSC119911V, NSC119910U, NSC128437O, NSC125908P, NSC9600Q, or NSC13778J, each obtained from the Structure Diversity Set, National Institutes of Health, National Cancer Institute, Developmental Therapeutics Program). These compounds are shown to be effective inhibitors of viral essential protein kinases (such as poxvirus B1 and/or F10 protein kinases). Exemplary chemical structures for viral protein kinase (VPK) inhibitors are provided, as are methods of using such compounds, for instance, to inhibit VPK activity and/or poxvirus growth, and/or for the treatment of poxvirus infection. Also provided are pharmaceutical compositions including disclosed VPK inhibitors.
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS
  申请人：Massachusetts Institute of Technology

  公开号：US20170051073A1

  公开（公告）日：2017-02-23

  Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyses of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.
• US8076375B2
  申请人：——

  公开号：US8076375B2

  公开（公告）日：2011-12-13