苯并[1,2-d:4,5-d']二咪唑-2(1H)-酮(6CI) | 50402-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 苯并[1,2-d:4,5-d']二咪唑-2(1H)-酮(6CI)
• 中文别名: N-乙酰基-N'-(5-磺基-1-萘基)乙二胺
• 英文名称: N-(Acetylaminoaethyl)-5-naphthylamin-1-sulfonsaeure
• 英文别名: 1,5-Aedans；5-(2-acetamidoethylamino)naphthalene-1-sulfonic acid
• CAS: 50402-62-5
• 化学式: C₁₄H₁₆N₂O₄S
• 分子量: 308.358
• InChiKey: FBZFLXJHAMMUQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090

文献信息

• Methods, compositions, and kits for detection of bacterial proteases
  申请人：CITY OF HOPE

  公开号：US10520496B2

  公开（公告）日：2019-12-31

  Provided herein are novel fluorogenic and bioluminescent bacterial protease substrates that contain at least one bacterial protease cleavage site. In some embodiments, the proteases that cleave the protease substrates are bacterial proteases including those used for tissue dissociation, cell isolation, and cell detachment, such as the preparation of islet cells. Additionally, the novel protease substrates described herein may be used to assess the activity of certain bacterial proteases involved in isolating primary cells and stem cells. Methods and protease detection kits using the novel protease substrates are also provided herein.

  本文提供的是新型萤光和生物发光细菌蛋白酶底物，其含有至少一个细菌蛋白酶裂解位点。在某些实施方案中，裂解蛋白酶底物的蛋白酶是细菌蛋白酶，包括用于组织解离、细胞分离和细胞脱落（如制备胰岛细胞）的细菌蛋白酶。此外，本文所述的新型蛋白酶底物还可用于评估某些参与分离原代细胞和干细胞的细菌蛋白酶的活性。本文还提供了使用新型蛋白酶底物的方法和蛋白酶检测试剂盒。
• Molecular sensors and uses thereof
  申请人：New York University

  公开号：US11242555B2

  公开（公告）日：2022-02-08

  The present disclosure provides molecular sensors. The molecular sensors may be flexible or linear and are oligonucleotide-based and have fluorescent groups. The molecular sensors may be used in methods to measure molecular crowding, identify of binding modes of various substrates, pharmaceutical drug screens, and in high-throughput methods.

  本公开提供分子传感器。分子传感器可以是柔性或线性的，以寡核苷酸为基础并带有荧光基团。分子传感器可用于测量分子拥挤度、识别各种底物的结合模式、药物筛选和高通量方法。
• FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION
  申请人：Lugade Ananda G.

  公开号：US20080103061A1

  公开（公告）日：2008-05-01

  The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.
• METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF BACTERIAL PROTEASES
  申请人：CITY OF HOPE

  公开号：US20190004036A1

  公开（公告）日：2019-01-03

  Provided herein are novel fluorogenic and bioluminescent bacterial protease substrates that contain at least one bacterial protease cleavage site. In some embodiments, the proteases that cleave the protease substrates are bacterial proteases including those used for tissue dissociation, cell isolation, and cell detachment, such as the preparation of islet cells. Additionally, the novel protease substrates described herein may be used to assess the activity of certain bacterial proteases involved in isolating primary cells and stem cells. Methods and protease detection kits using the novel protease substrates are also provided herein.
• MOLECULAR SENSORS AND USES THEREOF
  申请人：New York University

  公开号：US20200095627A1

  公开（公告）日：2020-03-26

  The present disclosure provides molecular sensors. The molecular sensors may be flexible or linear and are oligonucleotide-based and have fluorescent groups. The molecular sensors may be used in methods to measure molecular crowding, identify of binding modes of various substrates, pharmaceutical drug screens, and in high-throughput methods.