copper(II)(1,10-phenanthroline)3 | 20243-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: copper(II)(1,10-phenanthroline)3
• 英文别名: copper(II)tris(1,10-phenanthroline)；[Cu(1,10-phenanthroline)3](2+)；{Cuphan3}(2+)；rac-tris(1,10-phenanthroline)copper(II)；tris(1,10-phenanthroline)copper(II)；rac-[Cu(phen)3](2+)；copper;1,10-phenanthroline
• CAS: 20243-47-4
• 化学式: C₃₆H₂₄CuN₆
• 分子量: 604.173
• InChiKey: QEHDSCPBMJFYJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.35
• 重原子数：
  43
• 可旋转键数：
  0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 copper(II) nitrate 在 水 作用下， 以 水 为溶剂， 生成 copper(II)(1,10-phenanthroline)3
  参考文献：
  名称：

  铜（b）-bpy和-phen配合物的结构：水溶液中的2,2'-联吡啶和1,10-菲咯啉铜（II）配合物的EXAFS和分光光度法研究

  摘要：

  摘要用EXAFS和分光光度法研究了水溶液中2,2'-联吡啶（bpy）和1,10-菲咯啉（phen）的铜（II）配合物的结构。分别以[Cu（bpy）] 2 +，[Cu（bpy）2] 2+和[Cu（bpy）3] 2+络合物为主的溶液的EXAFS数据和电子光谱表明，单（ 2,2'-联吡啶）铜（II）配合物具有轴向拉长的八面体结构，具有四个其他水分子，而tris（2,2'-联吡啶）铜（II）配合物也具有扭曲的八面体结构。另一方面，双（2,2'-联吡啶）铜（II）配合物具有五坐标的三角双锥体结构，并带有一个额外的水分子。还显示了mono-和tris（1，10-菲咯啉）铜（II）络合物是轴向拉长的八面体，类似于相关的2,2'-联吡啶络合物。双（1,10-菲咯啉）铜（II）配合物的结构无法通过当前的传输模式EXAFS实验确定，因为它在水中的溶解度非常低。

  DOI：

  10.1016/s0020-1693(00)84937-3
• 作为试剂：
  描述：

  环庚烷 在 copper(II)(1,10-phenanthroline)3 、 双氧水 作用下， 以 水 为溶剂， 反应 3.0h， 生成 环庚醇 、 环庚酮
  参考文献：
  名称：

  Aluminum metal–organic framework as a new host for preparation of encapsulated metal complex catalysts

  摘要：

  A facile strategy for encapsulation of metal complex guests into MOFs was proposed. This strategy involves pre-adsorbing metal salt on MOF, and then coordinating the metal ions with the organic ligand, as exemplified by encapsulation of tris(1,10-phenanthroline) Cu(II) complexes (CuPhen) in MIL-100(Al) (denoted as CuPhen/MIL). CuPhen encapsulated in MIL-100(Al) showed higher catalytic activity than the neat CuPhen and CuPhen encapsulated in zeolite-Y. The prepared CuPhen/MIL catalyst was stable and could be reused at least three times without significant loss in activity. This work is beneficial for the host-guest chemistry study and the development of new heterogeneous catalysts. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2015.02.011

文献信息

• Fábián; Diebler, Inorganic Chemistry, 1987, vol. 26, # 6, p. 925 - 928
  作者：Fábián、Diebler

  DOI：——

  日期：——
• Paired-Cysteine Scanning Reveals Conformationally Sensitive Proximity between the TM4b-4c Loop and TM8 of the Glutamate Transporter EAAT1
  作者：Shaogang Qu、Wenlong Zhang、Suifen He、Xiuping Zhang

  DOI：10.1021/acschemneuro.9b00048

  日期：2019.5.15

  Excitatory amino acid transporters (EAATs) take up the neurotransmitter glutamate from the synaptic cleft and maintain glutamate concentrations below neurotoxic levels. Recently, the crystal structures of thermostable EAAT1 variants have been reported; however, little is understood regarding the functional mechanism of the transmembrane domain (TM) 4b-4c loop, which contains more than 50 amino acids in mammalian EAATs that are absent in prokaryotic homologues. To explore the spatial position and function of TM4 during the transport cycle, we introduced pairwise cysteine substitutions between the TM4b-4c loop and TM8 in a cysteine-less version of EAAT1, CL-EAAT1. We observed pronounced inhibition of transport by Cu(II)(1,10-phenanthroline)(3) (CuPh) for doubly substituted V238C/I469C and A243C/I469C variants, but not for corresponding singly substituted CL-EAAT1 or for more than 20 other double-cysteine variants. Dithiothreitol treatment partially restored the uptake activity of the CuPh-treated V238C/I469C and A243C/1469C doubly substituted variants, confirming that the effects of CuPh on these variants were due to the formation of intramolecular disulfide bonds. Glutamate, KCl, and D,L-threo-beta-benzyloxy-aspartate weakened CuPh inhibition of the V238C/I469C variant, but only KCl weakened CuPh inhibition of the V243C/1469C variant, suggesting that the TM4b-4c loop and TM8 are separated from each other in the inward-facing conformations of EAAT1. Our results suggest that the TM4b-4c loop and TM8 are positioned in close proximity during the transport cycle and are less closely spaced in the inward-facing conformation.
• Structure of copper(II)-bpy and -phen complexes: EXAFS and spectrophotometric studies on the structure of copper(II) complexes with 2,2′-bipyridine and 1,10-phenanthroline in aqueous solution
  作者：Kazuhiko Ozutsumi、Takuji Kawashima

  DOI：10.1016/s0020-1693(00)84937-3

  日期：1991.2

  octahedral structure with four additional water molecules and the tris(2,2′-bipyridine)copper(II) complex also has a distorted octahedral structure. On the other hand, the bis(2,2′-bipyridine)copper(II) complex has a five-coordinate trigonal bipyramidal structure with an additional water molecule. It was also shown that the structure of the mono- and tris(1,10-phenanthroline)copper(II) complexes is axially

  摘要用EXAFS和分光光度法研究了水溶液中2,2'-联吡啶（bpy）和1,10-菲咯啉（phen）的铜（II）配合物的结构。分别以[Cu（bpy）] 2 +，[Cu（bpy）2] 2+和[Cu（bpy）3] 2+络合物为主的溶液的EXAFS数据和电子光谱表明，单（ 2,2'-联吡啶）铜（II）配合物具有轴向拉长的八面体结构，具有四个其他水分子，而tris（2,2'-联吡啶）铜（II）配合物也具有扭曲的八面体结构。另一方面，双（2,2'-联吡啶）铜（II）配合物具有五坐标的三角双锥体结构，并带有一个额外的水分子。还显示了mono-和tris（1，10-菲咯啉）铜（II）络合物是轴向拉长的八面体，类似于相关的2,2'-联吡啶络合物。双（1,10-菲咯啉）铜（II）配合物的结构无法通过当前的传输模式EXAFS实验确定，因为它在水中的溶解度非常低。