1,1,2-Triphenyl-2--ethanol-(1)

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,1,2-Triphenyl-2--ethanol-(1)
• 英文别名: 1,1,2-triphenyl-2-piperidin-2-yl-ethanol；1,1,2-Triphenyl-2-piperidin-2-ylethanol
• 化学式: C₂₅H₂₇NO
• 分子量: 357.495
• InChiKey: AUODKWHKZOWZJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PROCESS FOR OBTAINING ENANTIOMERS OF THIENYLAZOLYLALCOXYETHANAMINES
  申请人：Jover Torrens Antoni

  公开号：US20060135787A1

  公开（公告）日：2006-06-22

  A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine and in general for thienylazolylalcoxyethanamines and their enantiomers. The process involves asymmetric addition of a metalated thienyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield the corresponding pharmaceutically active thienylazolylalcoxyethanamines.

  描述了一种制备(±)-2-[噻吩基(1-甲基-1H-吡唑-5-基)甲氧基]-N,N-二甲基乙胺前体醇的过程，以及噻吩基吡唑基醇和它们的对映体的一般制备方法。该过程涉及将金属化的噻吩试剂不对称加到吡唑醛中，在手性配体存在下生成手性醇。这些手性醇进一步进行O-烷基化，生成相应的具有药用活性的噻吩基吡唑基醇乙胺。
• Process for obtaining cizolirtine and its enantiomers
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1671953A1

  公开（公告）日：2006-06-21

  A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers, it comprises the asymmetric addition of a metalated phenyl reagent to an pyrazolcarbaldehyde in the presence of a chiral ligand to render chiral alcohols. The chiral alcohols are further O-alkylated to render Cizolirtine or its enantiomers.

  描述了一种制备Cizolirtine的前体醇，即(±)-2-[苯基(1-甲基-1H-吡唑-5-基)甲氧基]-N,N-二甲基乙胺及其对映体的过程，包括在手性配体存在下将金属化的苯基试剂不对称加成到吡唑醛中以生成手性醇。这些手性醇进一步进行O-烷基化以生成Cizolirtine或其对映体。
• Process for obtaining enantiomers of thienylazolylalcoxyethanamines
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1671968A1

  公开（公告）日：2006-06-21

  A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-NN-dimethyletanamine and in general for thyenylazolylalcoxyethanamines and their enantiomers. It comprises the asymmetric addition of a metalated thienyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to render chiral alcohols. The chiral alcohols are further O-alkylated to render the corresponding pharmaceutically active thyenylazolylalcoxyethanamines.

  描述了一种制备（±）-2-[噻吩基(1-甲基-1H-吡唑-5-基)甲氧基]-NN-二甲基乙胺前体醇以及一般噻吩基吡唑基甲氧基乙胺及其对映体的过程。该过程包括在手性配体存在下，将金属化的噻吩试剂不对称加到吡唑醛中，生成手性醇。进一步将手性醇进行O-烷基化，生成相应的具有药用活性的噻吩基吡唑基甲氧基乙胺。
• PROCESS FOR OBTAINING CIZOLIRTINE AND ITS ENANTIOMERS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1838678A1

  公开（公告）日：2007-10-03
• US7078531B2
  申请人：——

  公开号：US7078531B2

  公开（公告）日：2006-07-18