2-(p-Anisidinyl)naphthalene-6-sulfonic acid | 69287-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(p-Anisidinyl)naphthalene-6-sulfonic acid
• 英文别名: 6-(4-Methoxyanilino)naphthalene-2-sulfonic acid
• CAS: 69287-60-1
• 化学式: C₁₇H₁₅NO₄S
• 分子量: 329.376
• InChiKey: DFBWWSFAKXYLQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(p-Anisidinyl)naphthalene-6-sulfonic acid 、 β-环糊精 以 水 为溶剂， 生成
  参考文献：
  名称：

  Thermodynamic study on the effects of .beta.-cyclodextrin inclusion with anilinonaphthalenesulfonates

  摘要：

  Thermodynamic parameters and stoichiometries for the binding of anilinonaphthalenesulfonates to beta-cyclodextrin are obtained from steady-state fluorescence intensity and anisotropy measurements. Specifically, formation constant, enthalpy, and entropy values are obtained for complexes of beta-cyclodextrin with eight different substrate molecules at five different temperatures and six different pH values, and their associated errors are given. We propose an explanation of the relative magnitudes of the values obtained with regard to the geometry of the substrate and the importance of the various noncovalent interactions responsible for the complexation.

  DOI：

  10.1021/ac00183a024

文献信息

• Homogeneous fluorescence immunoassay using a light absorbing material
  申请人：Becton, Dickinson and Company

  公开号：EP0191575A1

  公开（公告）日：1986-08-20

  A method for separation-free solid phase immunoassay of an analyte includes contacting an anti-analyte attached to the surface of a solid support with the analyte, a light absorbing material and a fluorescent tracer for the analyte. The resulting mixture is incubated. The method includes applying excitation light to the mixture and time resolved measurement of fluorescence emission from the tracer. All excitation light and fluorescence emission are absorbed by the light absorbing material except that absorbed and emitted by the tracer bound to the anti-analyte whereby the only fluorescence emission detected is from the bound tracer. Since free tracer in the fluid phase of the assay medium does not emit fluorescence, separation of the bound and free fractions is unnecessary. The invention includes a kit of materials useful in performing an immunoassay in accordance with the method of the invention.

  一种对被分析物进行无分离固相免疫测定的方法，包括将附着在固体支持物表面的抗分析物与被分析物、光吸收材料和被分析物的荧光示踪剂接触。 将得到的混合物进行孵育。 该方法包括对混合物施加激发光并对示踪剂的荧光发射进行时间分辨测量。 所有激发光和荧光发射均被光吸收材料吸收，但与抗分析物结合的示踪剂吸收和发射的激发光和荧光除外，因此检测到的唯一荧光发射来自结合的示踪剂。 由于检测介质流体相中的游离示踪剂不发射荧光，因此无需分离结合和游离部分。 本发明包括一套材料，用于按照本发明的方法进行免疫测定。
• US4680275A
  申请人：——

  公开号：US4680275A

  公开（公告）日：1987-07-14
• Thermodynamic study on the effects of .beta.-cyclodextrin inclusion with anilinonaphthalenesulfonates
  作者：Gino C. Catena、Frank V. Bright

  DOI：10.1021/ac00183a024

  日期：1989.4.15

  Thermodynamic parameters and stoichiometries for the binding of anilinonaphthalenesulfonates to beta-cyclodextrin are obtained from steady-state fluorescence intensity and anisotropy measurements. Specifically, formation constant, enthalpy, and entropy values are obtained for complexes of beta-cyclodextrin with eight different substrate molecules at five different temperatures and six different pH values, and their associated errors are given. We propose an explanation of the relative magnitudes of the values obtained with regard to the geometry of the substrate and the importance of the various noncovalent interactions responsible for the complexation.