[(2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]-piperazin-1-ylmethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [(2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl]-piperazin-1-ylmethanone
• 化学式: C₁₈H₂₆N₂O₃
• 分子量: 318.4
• InChiKey: UBQNZKMELMBKHG-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 6-CHROMANOL DERIVATIVES FOR USE AS A MEDICAMENT
  申请人：Sulfateq B.V.

  公开号：EP3672592A1

  公开（公告）日：2020-07-01
• [EN] 6-CHROMANOL DERIVATIVES FOR USE AS A MEDICAMENT<br/>[FR] DÉRIVÉS DE 6-CHROMANOL DESTINÉS À ÊTRE UTILISÉS À TITRE DE MÉDICAMENT
  申请人：SULFATEQ BV

  公开号：WO2019038360A1

  公开（公告）日：2019-02-28

  The present invention relates to the (S) enantiomeric form of certain 6-chromanol derivatives for use as a medicament. Especially, the present invention relates to the (S) enantiomeric form of a 6-chromanol derivative for use as a medicament wherein said 6-chromanol derivative is chosen from the group consisting of (6-hydroxy-2,5,7,8-tetramethylchroman-2- yl)(piperazin-1-yl)methanone; N-(benzyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; N-(phenyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; methyl 4-(6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxamido)benzoate; (6-hydroxy-2,5,7,8-tetramethylchroman-2- yl)(morpholino)methanone, and pharmaceutically acceptable salts or bases thereof and pharmaceutically acceptable salts thereof.