2-methyl-3-oxo-3,4-dihydro-2H-1-benzopyran | 90843-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-methyl-3-oxo-3,4-dihydro-2H-1-benzopyran
• 英文别名: 2-Methyl-chromanon-(3)；2-methyl-chroman-3-one；Methyl-3-chromone；2-methyl-4H-chromen-3-one
• CAS: 90843-23-5
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: AZHFOZMCFQVLBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-diazo-3-phenoxy-2-butanone 生成 2-methyl-3-oxo-3,4-dihydro-2H-1-benzopyran
  参考文献：
  名称：

  PUSINO A.; SABA A.; ROSNATI V., TETRAHEDRON, 1986, 42, N 15, 4319-4324

  摘要：

  DOI：

文献信息

• Catalytic decomposition of branched α'-phenoxy-α-iazo ketones affording 2, 8h-cyclohepta[b]furan-3-one and 2h-cyclohepta[b]furan-3a(3ah)methyl-3-one
  作者：Alba Pusino、Antonio Saba、Vittorio Rosnati

  DOI：10.1016/s0040-4020(01)87658-4

  日期：——

  substitution. Mixtures of furanones 2 and chromanones 4 were obtained from α-unsubstituted substrates 1b–d, as in the case of 1a. Instead, among the α-mono substituted substrates 1f and 1g selectively gave cycloneptatrienes 3f and 3g, respectively, while 1e and 1h gave mixtures of the corresponding 3 and 4. Cycloheptatrienes 3 easily rearranged to chromanones 4. The intermediacy of norcaradienes 5 has

  研究了双（六氟乙酰乙酰丙酮）Cu II在α'-碳上带有苯氧基的支链α-重氮酮1上引起的分解。已经表明反应过程取决于取代。与1a的情况一样，呋喃酮2和发色酮4的混合物是从α-未取代的底物1b - d中获得的。取而代之的是，在α-单取代的底物1f和1g中，分别选择性地给出环庚烯3f和3g，而1e和1h给出相应的混合物。3和4。环庚三烯3容易重新排列为发色团4。norcaradienes的中间性5已初步在催化分解提出1，并且在重排3E - ħ至4E - ħ。
• [EN] CHROMENONE DERIVATIVES AS TRPV3 ANTAGONISTS<br/>[FR] DÉRIVÉS DE CHROMÉNONE CONVENANT COMME ANTAGONISTES DE TRPV3
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2010055384A1

  公开（公告）日：2010-05-20

  The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRP V3. (Formula I) (I)

  本发明提供了公式（I）的瞬时受体电位香草醛（TRPV）调节剂。特别地，本文描述的化合物可用于治疗或预防由TRPV3调节的疾病、状况和/或疾患。本文还提供了用于制备所述化合物的过程，用于合成它们的中间体，它们的制药组合物以及治疗或预防由TRPV3调节的疾病、状况和/或疾患的方法。（公式I）（I）
• CHROMENONE DERIVATIVES AS TRPV3 ANTAGONISTS
  申请人：Chaudhari Sachin Sundarlal

  公开号：US20110237659A1

  公开（公告）日：2011-09-29

  The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

  本发明提供了公式（I）的瞬时受体电位香草酰基（TRPV）调节剂。特别地，本文所描述的化合物可用于治疗或预防TRPV3调节的疾病、状况和/或障碍。本文还提供了用于制备所述化合物的过程、用于其合成的中间体、制药组合物以及用于治疗或预防TRPV3调节的疾病、状况和/或障碍的方法。
• PUSINO A.; SABA A.; ROSNATI V., TETRAHEDRON, 1986, 42, N 15, 4319-4324
  作者：PUSINO A.、 SABA A.、 ROSNATI V.

  DOI：——

  日期：——