methyl 4-(2-amino-3-cyano-4H-benzo[h]chromen-4-yl)benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: methyl 4-(2-amino-3-cyano-4H-benzo[h]chromen-4-yl)benzoate
• 化学式: C₂₂H₁₆N₂O₃
• 分子量: 356.381
• InChiKey: CCGKDWATTIAHEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 4-(2-amino-3-cyano-4H-benzo[h]chromen-4-yl)benzoate 在 N-氯代丁二酰亚胺 、 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 4.5h， 生成 methyl 4-(3-cyano-2-imino-2H-benzo[h]chromen-4-yl)benzoate
  参考文献：
  名称：

  An approach towards the oxidation of 2-amino-4H-chromenes to 2-imino-2H-chromenes

  摘要：

  A novel method for the synthesis of 2-imino-2H-benzo[h]chromenes via the sequential addition of N-chlorosuccinimide and triethylamine to 2-amino-4H-benzo[h]chromenes has been established. This reaction protocol represents an efficient synthetic strategy to form iminochromene derivatives under mild reaction conditions, which utilizes readily accessible aminochromenes as starting materials and tolerates a wide range of substrates. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2018.11.046

文献信息

• An approach towards the oxidation of 2-amino-4H-chromenes to 2-imino-2H-chromenes
  作者：Manohar Mantipally、Rambabu Gundla、Madhusudhana Reddy Gangireddy、Viswanathan Vijayan、Velmurugan Devadasan

  DOI：10.1016/j.tetlet.2018.11.046

  日期：2018.12

  A novel method for the synthesis of 2-imino-2H-benzo[h]chromenes via the sequential addition of N-chlorosuccinimide and triethylamine to 2-amino-4H-benzo[h]chromenes has been established. This reaction protocol represents an efficient synthetic strategy to form iminochromene derivatives under mild reaction conditions, which utilizes readily accessible aminochromenes as starting materials and tolerates a wide range of substrates. (C) 2018 Elsevier Ltd. All rights reserved.