7,8-dimethoxy-4,5-dihydro-1(2)H-benzo[g]indazole | 57595-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7,8-dimethoxy-4,5-dihydro-1(2)H-benzo[g]indazole
• 英文别名: 7,8-dimethoxy-4,5-dihydro-1H-benzo[g]indazole
• CAS: 57595-66-1
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: NACRDJZYQHMAAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
  申请人：PTC Therapeutics, Inc.

  公开号：EP2363129A1

  公开（公告）日：2011-09-07

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

  本发明涉及通过施用本发明的化合物或组合物治疗或预防与 mRNA 中无义突变相关的疾病的方法、化合物和组合物。更具体地说，本发明涉及抑制与 mRNA 中无义突变相关的过早翻译终止的方法、化合物和组合物。