α-naphthol - 1,4-naphthoquinone 1:1 complex | 144742-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: α-naphthol - 1,4-naphthoquinone 1:1 complex
• 英文别名: [1,4]naphthoquinone; compound with naphthol-(1)；[1,4]Naphthochinon; Verbindung mit Naphthol-(1)；[1,4]Naphthochinon; Verbindung von α-Naphthochinon mit α-Naphthol；Naphthalene-1,4-dione;naphthalen-1-ol
• CAS: 144742-24-5
• 化学式: C₁₀H₆O₂*C₁₀H₈O
• 分子量: 302.329
• InChiKey: NMJXDHYHNATPKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MUTANTS OF UNSPECIFIC PEROXYGENASE WITH HIGH MONOOXYGENASE ACTIVITY AND USES THEREOF
  申请人：Consejo Superior De Investigaciones Científicas (CSIC)

  公开号：EP3375869A1

  公开（公告）日：2018-09-19

  The invention relates to an unspecific peroxygenase of the Agrocybe aegerita fungus, obtained by means of directed molecular evolution to facilitate the functional expression thereof in an active, soluble and stable form. The peroxygenase described in the invention shows a significant improvement in the functional expression thereof, improved monooxygenase activity and reduced peroxidase activity, in relation to the monooxygenase and peroxidase activities showed by the unspecific wild-type peroxygenase of A. aegerita. The peroxygenase of the invention is useful in chemical processes, including industrial transformations such as the selective oxyfunctionalisation of carbon-hydrogen bonds of various organic compounds.

  本发明涉及一种 Agrocybe aegerita 真菌的非特异性过氧化氢酶，它是通过定向分子进化的方法获得的，以促进其活性、可溶性和稳定形式的功能表达。与 A. aegerita 的非特异性野生型过氧化物酶所显示的单氧化酶和过氧化物酶活性相比，本发明所述的过氧化物酶在其功能表达、单氧化酶活性提高和过氧化物酶活性降低方面有显著改善。本发明的过氧化氢酶可用于化学过程，包括工业转化，如各种有机化合物碳氢键的选择性氧官能化。
• Polynucleotide, host cell and a method to recombinantly produce the protein encoded by said polynucleotide having peroxygenative activity
  申请人：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

  公开号：US10876098B2

  公开（公告）日：2020-12-29

  The invention relates to an unspecific peroxygenase of the Agrocybe aegerita fungus, obtained by means of directed molecular evolution to facilitate the functional expression thereof in an active, soluble and stable form. The peroxygenase described in the invention shows a significant improvement in the functional expression thereof, improved monooxygenase activity and reduced peroxidase activity, in relation to the monooxygenase and peroxidase activities showed by the unspecific wild-type peroxygenase of A. aegerita. The peroxygenase of the invention is useful in chemical processes, including industrial transformations such as the selective oxyfunctionalisation of carbon-hydrogen bonds of various organic compounds.

  本发明涉及一种 Agrocybe aegerita 真菌的非特异性过氧化氢酶，它是通过定向分子进化的方法获得的，以促进其活性、可溶性和稳定形式的功能表达。与 A. aegerita 的非特异性野生型过氧化物酶所显示的单氧化酶和过氧化物酶活性相比，本发明所述的过氧化物酶在其功能表达、单氧化酶活性提高和过氧化物酶活性降低方面有显著改善。本发明的过氧化氢酶可用于化学过程，包括工业转化，如各种有机化合物碳氢键的选择性氧官能化。