1-(4-Butylpiperazin-1-yl)hexadecan-2-ol | 1355166-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(4-Butylpiperazin-1-yl)hexadecan-2-ol
• CAS: 1355166-14-1
• 化学式: C₂₄H₅₀N₂O
• 分子量: 382.674
• InChiKey: WQYBROUCJJGFSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-丁基哌嗪 、 1,2-环氧十六烷 在 甲醇 作用下， 反应 24.0h， 以70%的产率得到1-(4-Butylpiperazin-1-yl)hexadecan-2-ol
  参考文献：
  名称：

  Diamine and aminoalcohol derivatives active against Trypanosoma brucei

  摘要：

  Twenty compounds selected as representative members of three series of long-chain 1,2-diamines, 2-amino-1-alkanols and 1-amino-2-alkanols structurally related to dihydrosphingosin, were synthesized and tested in vitro for their ability to inhibit the sleeping sickness parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Eight compounds showed EC50 values in the submicromolar range, with selectivity indexes up to 39 related to the respective cytotoxicity values for Vero cells. The parasite phenotype detected after treatment with the most potent compounds showed irreversible cell morphology alterations of the flagellar pocket that lead to inhibition of cell growth and parasite death. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.108

文献信息

• Diamine and aminoalcohol derivatives active against Trypanosoma brucei
  作者：Esther del Olmo、Rosario Diaz-González、Ricardo Escarcena、Luis Carvalho、Luis A. Bustos、Miguel Navarro、Arturo San Feliciano

  DOI：10.1016/j.bmcl.2011.10.108

  日期：2012.1

  Twenty compounds selected as representative members of three series of long-chain 1,2-diamines, 2-amino-1-alkanols and 1-amino-2-alkanols structurally related to dihydrosphingosin, were synthesized and tested in vitro for their ability to inhibit the sleeping sickness parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Eight compounds showed EC50 values in the submicromolar range, with selectivity indexes up to 39 related to the respective cytotoxicity values for Vero cells. The parasite phenotype detected after treatment with the most potent compounds showed irreversible cell morphology alterations of the flagellar pocket that lead to inhibition of cell growth and parasite death. (C) 2011 Elsevier Ltd. All rights reserved.