N-(4-ethoxy-1,3-benzothiazol-2-yl)-3-methoxynaphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-ethoxy-1,3-benzothiazol-2-yl)-3-methoxynaphthalene-2-carboxamide
• 化学式: C₂₁H₁₈N₂O₃S
• 分子量: 378.4
• InChiKey: ABQPIARPEYPHGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Inhibitors of bacterial IMPDH
  申请人：Charifson Paul

  公开号：US20070191434A1

  公开（公告）日：2007-08-16

  The present invention relates to methods of inhibiting bacterial IMPDH comprising administering compounds of formula I: or pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infections.
• US8202889B2
  申请人：——

  公开号：US8202889B2

  公开（公告）日：2012-06-19
• [EN] INHIBITORS OF BACTERIAL IMPDH<br/>[FR] INHIBITEURS D'INOSINE-5'-MONOPHOSPHATE DESHYDROGENASE (IMPDH) BACTERIENNE
  申请人：VERTEX PHARMA

  公开号：WO2007030617A1

  公开（公告）日：2007-03-15

  [EN] The present invention relates to methods of inhibiting bacterial IMPDH comprising administering compounds of formula I: or pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infections.
  [FR] Procédés d'inhibition d'IMPDH bactérienne par administration de composés de formule I ou de sels pharmaceutiquement acceptables. Egalement, compositions pharmaceutiquement acceptables renfermant lesdits composés. Les composés et les compositions qui les renferment sont utiles pour le traitement d'infections bactériennes.