Ethyl 2-amino-4-(3,4,5-trimethoxyphenyl)-3-thiophenecarboxylate | 35978-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: Ethyl 2-amino-4-(3,4,5-trimethoxyphenyl)-3-thiophenecarboxylate
• 英文别名: ethyl 2-amino-4-(3,4,5-trimethoxyphenyl)thiophene-3-carboxylate
• CAS: 35978-32-6
• 化学式: C₁₆H₁₉NO₅S
• 分子量: 337.4
• InChiKey: RVZLFQWKEAQNFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Ethyl 2-amino-4-(3,4,5-trimethoxyphenyl)-3-thiophenecarboxylate 、 苯甲醛 以100%的产率得到
  参考文献：
  名称：

  KOEBEL R. F.; NEEDHAM L. L.; BLANTON JR. C. D., J. MED. CHEM. , 1975, 18, NO 2, 192-194

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (E)-2-cyano-3-(3,4,5-trimethoxyphenyl)but-2-enoate 以50%的产率得到
  参考文献：
  名称：

  KOEBEL R. F.; NEEDHAM L. L.; BLANTON JR. C. D., J. MED. CHEM. , 1975, 18, NO 2, 192-194

  摘要：

  DOI：

文献信息

• COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
  申请人：VELICELEBI GONUL

  公开号：US20110212970A1

  公开（公告）日：2011-09-01

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文介绍了一些化合物和含有这些化合物的药物组合物，它们可以调节储存操作钙（SOC）通道的活性。本文还介绍了使用这些SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或情况。
• Substituted thiophene modulators of intracellular calcium
  申请人：CalciMedica, Inc.

  公开号：US07906553B2

  公开（公告）日：2011-03-15

  Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了具有以下结构的公式（I）化合物：其中A、J、R1、R4、Z和X在此处描述；以及含有这种化合物的药物组合物，这些组合物调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或病况。
• Trisubstituted thiophenes that modulate intracellular calcium
  申请人：Velicelebi Gonul

  公开号：US08383670B2

  公开（公告）日：2013-02-26

  Described herein are compounds of Formula (I): wherein A, J, Z, X, R1, and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了公式（I）的化合物： 其中A，J，Z，X，R1和R4在此定义，并且包含这种化合物的制药组合物，可调节储存操作钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或病症。
• Compounds that modulate intracellular calcium
  申请人：Velicelebi Gonul

  公开号：US08394848B2

  公开（公告）日：2013-03-12

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

  本文描述了含有这些化合物的药物组合物，这些化合物调节储存操作钙离子（SOC）通道的活性。还描述了使用这种SOC通道调节剂的方法，单独或与其他化合物结合，用于治疗需要抑制SOC通道活性的疾病或病症。
• US7906553B2
  申请人：——

  公开号：US7906553B2

  公开（公告）日：2011-03-15