1,3-Dihydronaphtho<2,3-c>thiophen | 58948-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,3-Dihydronaphtho<2,3-c>thiophen
• 英文别名: 5,6-Benzo-1,3-dihydro-isothionaphthen；1,3-dihydro-naphtho[2,3-c]thiophene；1,3-Dihydronaphtho[2,3-c]thiophene；1,3-dihydrobenzo[f][2]benzothiole
• CAS: 58948-53-1
• 化学式: C₁₂H₁₀S
• 分子量: 186.277
• InChiKey: GJSDSQMOVFARPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same
  申请人：——

  公开号：US20030078277A1

  公开（公告）日：2003-04-24

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. 1 Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR 1 R 2 ) m — (wherein R 1 and R 2 are the same as or different from each other and each represents a C 1-6 alkyl group etc.), —NR 3 — (wherein R 3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR 6 R 7 ) p — (wherein R 6 and R 7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C 1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C 1-6 alkyl group etc.; and the partial structure means a single or double bond.

  本发明提供了一种具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新化合物。即提供了由以下公式表示的化合物，其药理学上可接受的盐或水合物。其中A、B和D相互相同或不同，每个代表以下公式表示的基团：—(CR1R2)m—（其中R1和R2相互相同或不同，每个代表C1-6烷基等），—NR3—（其中R3代表氢等）等；E和G相互相同或不同，每个代表以下公式表示的基团：—(CR6R7)p—（其中R6和R7相互相同或不同，每个代表氢等；p代表0、1或2的整数）；J代表一个碳原子或氮原子，每个都被C1-6烷基等可选择地取代的卤素原子等取代；K和L相互相同或不同，每个代表碳原子或氮原子；M代表氢、卤素原子、可选择地取代的C1-6烷基等；部分结构表示单键或双键。
• Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it
  申请人：Hibi Shigeki

  公开号：US20050004159A1

  公开（公告）日：2005-01-06

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR 1 R 2 ) m — (wherein R 1 and R 2 are the same as or different from each other and each represents a C 1-6 alkyl group etc.), —NR 3 — (wherein R 3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR 6 R 7 ) p — (wherein R 6 and R 7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C 1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C 1-6 alkyl group etc.; and the partial structure means a single or double bond.

  本发明提供了一种具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新化合物。即，本发明提供了由以下式表示的化合物，其药学上可接受的盐或水合物。其中，A、B和D相同或不同，每个代表由公式—（CR1R2）m—（其中R1和R2相同或不同，每个代表C1-6烷基等）、—NR3—（其中R3表示氢等）等表示的基团；E和G相同或不同，每个代表由公式—（CR6R7）p—（其中R6和R7相同或不同，每个代表氢等；p表示0、1或2的整数）表示的基团；J代表一个碳原子或氮原子，每个用C1-6烷基取代，可选择用卤原子等取代；K和L相同或不同，每个代表碳原子或氮原子；M表示氢、卤原子、可选择用取代的C1-6烷基等取代；而部分结构表示单键或双键。
• SOLID ELECTROLYTIC CAPACITOR AND PROCESS FOR THE PRODUCTION THEREOF
  申请人：Showa Denko K K

  公开号：EP0971382A1

  公开（公告）日：2000-01-12

  A solid electrolytic capacitor includes a valve acting metal having microfine pores, a dielectric film formed on a surface of the valve acting metal, and a solid electrolyte layer provided on the dielectric film, in which at least a portion of the solid electrolyte layer is of a lamellar structure. In particular, a solid electrolytic capacitor includes an electrically conducting polymer having a specified condensed ring structure containing (1) a solid electrolyte layer containing a sulfoquinone anion having a sulfo anion group and a quinone structure and other anion, and (2) a solid electrolyte layer containing an anthracenesulfonate ion and other anion.

  固体电解电容器包括具有微细孔隙的阀门作用金属、形成于阀门作用金属表面的介电膜以及设置在介电膜上的固体电解质层，其中固体电解质层的至少一部分为片状结构。具体而言，固体电解电容器包括具有特定缩合环结构的导电聚合物，其中包含（1）含有磺醌阴离子的固体电解质层，该阴离子具有磺阴离子基团和醌结构以及其他阴离子；以及（2）含有蒽磺酸离子和其他阴离子的固体电解质层。
• CONDUCTIVE POLYMER, SOLID ELECTROLYTIC CAPACITOR, AND PROCESSES FOR PRODUCING THESE
  申请人：Showa Denko Kabushiki Kaisha

  公开号：EP1028440A1

  公开（公告）日：2000-08-16

  The present invention relates to a solid electrolytic capacitor comprising an electrode produced by forming a solid electrolytic layer comprised by a polymer having at least one repeating unit selected from a thiophene-diyl skeleton, an isothianaphthene-diyl skeleton, a pyrrole-diyl skeleton, a furan-diyl skeleton and an iminophenylene skeleton and having a fibril structure on a dielectric film layer of a porous valve-acting metal and its production method, and to a highly electroconductive polymer obtained by chemical oxidative polymerization of a monomer and an oxidizing agent at an interface and its production method.

  本发明涉及一种固体电解电容器，该电容器包括通过形成固体电解层而产生的电极，固体电解层由具有至少一个重复单元的聚合物构成，该重复单元选自噻吩二基骨架、异噻吩二基骨架、吡咯二基骨架、呋喃二基骨架和亚氨基苯基骨架、 呋喃二基骨架和亚氨基苯基骨架并在多孔阀动金属的介电膜层上具有纤维结构的聚合物及其生产方法，以及通过单体和氧化剂在界面上的化学氧化聚合得到的高导电性聚合物及其生产方法。
• FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME
  申请人：Eisai Co., Ltd.

  公开号：EP1238979A1

  公开（公告）日：2002-09-11

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula - (CR1R2)m- (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), -NR3- (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula - (CR6R7)p- (wherein R6 and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C1-6 alkyl group etc.; and the partial structure ----- means a single or double bond.

  本发明提供了一种新型化合物，它具有优异的促肾上腺皮质激素释放因子受体拮抗活性。也就是说，本发明提供了由下式表示的化合物、其药理学上可接受的盐或其水合物。 其中 A、B 和 D 彼此相同或不同，且各自代表由式 - (CR1R2)m- （其中 R1 和 R2 彼此相同或不同，且各自代表 C1-6 烷基等）、-NR3-（其中 R3 代表氢等）等表示的基团；E 和 G 彼此相同或不同，且各自代表由式 - (CR6R7)p- （其中 R6 和 R7 彼此相同或不同，且各自代表氢等）表示的基团。其中 R6 和 R7 彼此相同或不同，各自代表氢等；p 代表 0、1 或 2 的整数）；J 代表碳原子或氮原子，各自被 C1-6 烷基任选取代，并被卤素原子等取代；K 和 L 彼此相同或不同，各自代表碳原子或氮原子；M 指氢、卤素原子、任选取代的 C1-6 烷基等；部分结构 ----- 指单键或双键。