N,N-二甲基-4-(1-哌嗪)苯胺 | 91703-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: N,N-二甲基-4-(1-哌嗪)苯胺
• 英文名称: N-(4-dimethylamino-phenyl)-piperazine
• 英文别名: N,N-dimethyl-4-(piperazin-1-yl)aniline；1-(4-dimethylaminophenyl)piperazine；dimethyl(4-piperazin-1-ylphenyl)amine；N-1-(4-Dimethylaminophenyl)piperazine；Dimethyl-(4-piperazin-1-YL-phenyl)-amine；N,N-dimethyl-4-piperazin-1-ylaniline
• CAS: 91703-23-0
• 化学式: C₁₂H₁₉N₃
• mdl: MFCD03444415
• 分子量: 205.303
• InChiKey: GRJIAPLFQXLDJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  365.5±27.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-二甲基-4-(1-哌嗪)苯胺 在 sodium hydroxide 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 63.0h， 生成 5-[[4-(4-二甲基氨基苯基)哌嗪-1-基]甲基]-4,5-二氢-1,3-恶唑-2-胺
  参考文献：
  名称：

  Synthesis and antidepressant activity of 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines

  摘要：

  The synthesis of 20 5-(1-aryl-4-piperazino)methyl-2-amino-2-oxazolines is described. Antidepressant activity was observed in mice using classical screening tests. Structure-activity relationships were studied and correlated with the nature of the aromatic substituent. Preliminary lipophilic and electronic properties of one lead compound (COR 3224) have been described.

  DOI：

  10.1016/0223-5234(92)90177-3
• 作为产物：
  描述：

  N-benzyl-N'-(4-dimethylaminophenyl)-piperazine 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 反应 71.0h， 以0.379 g的产率得到N,N-二甲基-4-(1-哌嗪)苯胺
  参考文献：
  名称：

  Conformational Dynamics of Charge-Transfer States in Donor−Bridge−Acceptor Systems

  摘要：

  DOI：

  10.1002/1099-0690(200108)2001:16<3105::aid-ejoc3105>3.0.co;2-i

文献信息

• Substituted phenyl piperazinyl pyrrolidin-2-ones and related compounds
  申请人：Rhone-Poulenc Sante

  公开号：US04547504A1

  公开（公告）日：1985-10-15

  Pyrrolidine derivatives of the formula: ##STR1## wherein X represents an oxygen or sulphur atom, R represents a hydrogen atom or an alkyl radical, R.sub.o represents a hydrogen atom, an alkyl radical or a phenyl radical optionally substituted by a halogen atom or by an alkyl, alkoxy, alkylthio or nitro radical, A represents a nitrogen atom or a radical .dbd.CH--, the symbol Y represents a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, alkylcarbonyl, nitro, amino, alkylcarbonylamino, alkylamino, dialkylamino, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, cyano, trifluoromethyl, hydroxy, mercapto, alkylcarbonyloxy or alkylcarbonylthio radical, n represents zero or 1, and p represents 1, 2 or 3, it being understood that the alkyl and alkoxy radicals, and alkyl and alkoxy moieties of any of the aforementioned groups, contain from 1 to 4 carbon atoms are new therapeutically useful compounds, more particularly useful as antidepressants.

  吡咯烷衍生物的化学式为：##STR1## 其中X代表氧或硫原子，R代表氢原子或烷基基团，R.sub.o代表氢原子、烷基基团或苯基基团，该苯基基团可以选择性地被卤原子、烷基、烷氧基、烷硫基或硝基基团取代，A代表氮原子或.dbd.CH--基团，符号Y代表氢或卤原子或烷基、烷氧基、烷硫基、烷羰基、硝基、氨基、烷羰胺基、烷基氨基、二烷基氨基、烷基砜基、烷基砜酰基、烷氧羰基、氰基、三氟甲基、羟基、巯基、烷基羰氧基或烷基羰硫基基团，n代表零或1，p代表1、2或3，其中烷基和烷氧基基团以及任何上述基团的烷基和烷氧基部分含有1至4个碳原子，是新的具有治疗用途的化合物，特别适用作抗抑郁药。
• Pyrrolo-pyridine derivatives
  申请人：Merck Sharpe & Dohme Ltd.

  公开号：US05432177A1

  公开（公告）日：1995-07-11

  A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.

  一类吡咯并[2,3-b]吡啶衍生物，其在3位被取代的哌嗪甲基基团是大脑内多巴胺受体亚型的拮抗剂，具有对多巴胺D.sub.4受体亚型的选择性亲和力，相比经典的神经阻滞药物，对治疗和/或预防精神分裂症等精神障碍有益，并表现出较少的副作用。
• Substituted acylpiperazine derivatives
  申请人：Alberati-Giani Daniela

  公开号：US20050059668A1

  公开（公告）日：2005-03-17

  The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

  该发明涉及以下式中的化合物，其中取代基如规范中定义，并且其药用可接受的酸盐。该发明还涉及治疗精神病、疼痛、记忆和学习中的神经退行性功能障碍、精神分裂症、痴呆症以及其他认知过程受损的疾病的方法，如注意力缺陷障碍或阿尔茨海默病。
• Benzimidazole derivatives, preparation and therapeutic use thereof
  申请人：——

  公开号：US20030203893A1

  公开（公告）日：2003-10-30

  The invention relates to benzimidazole derivatives of general formula 1 in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom: R3 represents a hydrogen atom or a C1-C4 alkyl group, or does not exist, to give the compounds of formula (I) comprising a secondary or tertiary amine; R4 represents a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, optionally substituted C3-C7 heterocycloalkyl, —(CH 2 ) p -heteroaryl, heteroaryl-carbonyl, phenylcarbonyl, (C1-C6)alkylcarbonyl, —(CH 2 ) p COOR, optionally substituted phenylsulphonyl or optionally substituted —(CH 2 ) p -phenyl group, and, when X represents a carbon atom: p2 R3 represents a hydrogen atom or a group —NR5R6, —N(R5) 3 + , —NHCOR7, —CONHR5, —COR7, —NHCONH 2 , —OH or —CH 2 OH, R4 represents a hydrogen atom or an optionally substituted —(CH 2 ) p -phenyl, —(CH 2 ) p -heteroaryl or —(CH 2 ) t NR7R8 group. Preparation process and therapeutic application.

  该发明涉及一般式1的苯并咪唑衍生物，其中X代表氮原子或碳原子；当X代表氮原子时：R3代表氢原子或C1-C4烷基基团，或不存在，以给出包含二级或三级胺的式(I)化合物；R4代表氢原子或C1-C6烷基，C3-C7环烷基，可选择取代的C3-C7杂环烷基，—(CH2)p-杂环芳基，杂环芳基-酰基，苯基-酰基，(C1-C6)烷基酰基，—(CH2)pCOOR，可选择取代的苯磺酰基或可选择取代的—(CH2)p-苯基；当X代表碳原子时：R3代表氢原子或基团—NR5R6，—N(R5)3+，—NHCOR7，—CONHR5，—COR7，—NHCONH2，—OH或—CH2OH，R4代表氢原子或可选择取代的—(CH2)p-苯基，—(CH2)p-杂环芳基或—(CH2)tNR7R8基团。制备过程和治疗应用。
• 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
  申请人：Tsubouchi Hidetsugu

  公开号：US20060094767A1

  公开（公告）日：2006-05-04

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物，其通式如下：其中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R2代表—OR3或类似的基团，R3代表氢原子、C1-C6烷基或类似的基团，或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环，其通式为（H）：其中，R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。