2-phenyl-1,3-dioxane glycidyl ether | 130776-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-phenyl-1,3-dioxane glycidyl ether
• 英文别名: 2-O-(2',3'-epoxypropyl)-1,3-O-benzylideneglycerol；5-(Oxiran-2-ylmethoxy)-2-phenyl-1,3-dioxane
• CAS: 130776-77-1
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: VYPPWWQNFNRWEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  40.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环氧氯丙烷 、 2-苯基-1,3-二氧六环-5-醇 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-phenyl-1,3-dioxane glycidyl ether
  参考文献：
  名称：

  Fluorine-containing 2-nitroimidazole derivatives

  摘要：

  这是一种2-硝基咪唑衍生物，其化学式为：##STR1## 其中R.sub.f是以下式子（II）或（III）的基团：--CH.sub.2 CFXCH.sub.2 OR.sub.1（II）其中X是氢原子或卤素原子；R.sub.1是以下式子的基团：##STR2## 其中R.sub.2是氢原子、羟基、C.sub.1-C.sub.3烷基、C.sub.2-C.sub.4酰基、苯甲醛基或乙酰基；R.sub.3是氢原子或C.sub.1-C.sub.3烷基；Z是氢原子、COOY、COOR.sub.3、CONHOY、CONR.sub.4 R.sub.5（其中R.sub.4和R.sub.5是含有羟基的C.sub.1-C.sub.3烷基或氢原子；Y是氢原子或一价金属原子），氨基、羟基或OR.sub.3；l是1到3的整数；o是0到3的整数；p是0到2的整数；q是0到3的整数；m和n是0到4的整数；且1≤m+n≤4或##STR3## 其中R.sub.3、X和p的定义与上述相同；Z'与Z相同或为OCOOCH.sub.3；r是1到3的整数；s为0或1；t是0到4的整数，但当p=0时，s≠0且至少一个X为氟原子；以及包含该硝基咪唑衍生物的放射敏化剂。

  公开号：

  US04977273A1

文献信息

• Fluorine-containing 2-nitroimidazole derivatives
  申请人：Kyoto University of Honmachi

  公开号：US04977273A1

  公开（公告）日：1990-12-11

  A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III): --CH.sub.2 CFXCH.sub.2 OR.sub.1 (II) wherein X is a hydrogen atom or a halogen atom; R.sub.1 is a group of the formula: ##STR2## wherein R.sub.2 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkyl group, a C.sub.2 -C.sub.4 acyl group, benzylidene or acetonide; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; Z is a hydrogen atom, COOY, COOR.sub.3, CONHOY, CONR.sub.4 R.sub.5 (wherein R.sub.4 and R.sub.5 are hydroxyl group-containing C.sub.1 -C.sub.3 alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR.sub.3 ; l is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1.ltoreq.m+n.ltoreq.4 or ##STR3## wherein R.sub.3, X and p are the same as defined above; Z' is the same as Z or is OCOOCH.sub.3 ; r is an integer of 1 to 3; s is 0 or 1; t is an integer of 0 to 4 provided that when p=0, s.noteq.0 and at least one X is a fluorine atom; and a radiosensitizer comprising said nitroimidazole derivative.

  这是一种2-硝基咪唑衍生物，其化学式为：##STR1## 其中R.sub.f是以下式子（II）或（III）的基团：--CH.sub.2 CFXCH.sub.2 OR.sub.1（II）其中X是氢原子或卤素原子；R.sub.1是以下式子的基团：##STR2## 其中R.sub.2是氢原子、羟基、C.sub.1-C.sub.3烷基、C.sub.2-C.sub.4酰基、苯甲醛基或乙酰基；R.sub.3是氢原子或C.sub.1-C.sub.3烷基；Z是氢原子、COOY、COOR.sub.3、CONHOY、CONR.sub.4 R.sub.5（其中R.sub.4和R.sub.5是含有羟基的C.sub.1-C.sub.3烷基或氢原子；Y是氢原子或一价金属原子），氨基、羟基或OR.sub.3；l是1到3的整数；o是0到3的整数；p是0到2的整数；q是0到3的整数；m和n是0到4的整数；且1≤m+n≤4或##STR3## 其中R.sub.3、X和p的定义与上述相同；Z'与Z相同或为OCOOCH.sub.3；r是1到3的整数；s为0或1；t是0到4的整数，但当p=0时，s≠0且至少一个X为氟原子；以及包含该硝基咪唑衍生物的放射敏化剂。
• Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
  申请人：KYOTO UNIVERSITY

  公开号：EP0373630A1

  公开（公告）日：1990-06-20

  A 2-nitroimidazole derivative of the formula: wherein Rf is a group of the following formula (II) or (III): -CH₂CFXCH₂OR₁      (II) wherein X is a hydrogen atom or a halogen atom; R₁ is a group of the formula: -CH(CH₂OR₂)₂ -(CH₂)ℓOR₂ -(CH₂)ℓCOR₂ or wherein R₂ is a hydrogen atom, a hydroxyl group, a C₁-C₃ alkyl group, a C₂-C₄ acyl group, benzylidene or acetonide; R₃ is a hydrogen atom or a C₁-C₃ alkyl group; Z is a hydrogen atom, COOY, COOR3, CONHOY, CONR₄R₅ (wherein R₄ and R₅ are hydroxyl group-containing C₁-C₃ alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR₃; ℓ is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1 ≦ m + n ≦ 4 or wherein R₃, X and p are the same as defined above; Z′ is the same as Z or is OCOOCH₃; r is an integer of 1 to 3; s is 0 or 1; t is an integer of 0 to 4 provided that when p = 0, s ≠ 0 and at least one X is a fluorine atom; and a radiosensitizer comprising said nitroimidazole derivative.

  式中的 2-硝基咪唑衍生物： 其中 Rf 为下式(II)或(III)的基团： -CH₂CFXCH₂OR₁ (II) 其中 X 是氢原子或卤素原子；R₁ 是下式中的基团： -CH(CH₂OR₂)₂ -(CH₂)ℓOR₂ -(CH₂)ℓCOR₂或 其中 R₂ 是氢原子、羟基、C₁-C₃ 烷基、C₂-C₄酰基、亚苄基或丙酮；R₃ 是氢原子或 C₁-C₃ 烷基；Z 是氢原子、COOY、COOR3、CONHOY、CONR₄R₅（其中 R₄ 和 R₅ 是含羟基的 C₁-C₃ 烷基或氢原子；Y 是氢原子或一价金属原子）、氨基、羟基或 OR₃； ℓ 是 1 至 3 的整数； o 是 0 至 3 的整数； p 是 0 至 2 的整数； q 是 0 至 3 的整数； m 和 n 是 0 至 4 的整数；且 1 ≦ m + n ≦ 4 或 其中R₃、X和p与上文所定义的相同；Z′与Z相同或为OCOOCH₃；r为1至3的整数；s为0或1；t为0至4的整数，条件是当p＝0时，s≠0，且至少一个X为氟原子；以及包含所述硝基咪唑衍生物的放射增敏剂。
• US4977273A
  申请人：——

  公开号：US4977273A

  公开（公告）日：1990-12-11
• Multihydroxyl-Functional Polystyrenes in Continuous Flow
  作者：Christoph Tonhauser、Daniel Wilms、Frederik Wurm、Elena Berger Nicoletti、Michael Maskos、Holger Löwe、Holger Frey

  DOI：10.1021/ma902849r

  日期：2010.7.13

  We describe the synthesis of end-functionalized polystyi ems by living anionic polymerization in a micio;tructured reactor via termination by acetal-protected functional epoxidcs Initiation of styiene polymerization by alkyllithium takes place in a nucromixing device with efficient heat and mass transfer properties A newly developed continuous polymerization termination sequence enabled quantitative funetionalization of the living carbanions by nucicophilic displacement with dilfelent, specifically designed ulyeadyl edicts (ethoxy ethyl ulycidyl ether (EEGE). 1,2-isopropyhdenc glyce)'l glycidyl ether (IGG), and trans-2-phenyl-1,3-dioxanc glycidyl ether (PDGE)) Upon acidic hydrolysis the end-capped polystyrenes release multiple hydroxyl groups (2-3) at the chain end Tempel attire and flow rates have been vaned to control molecular weights and to optimize the reaction conditions I'm maximum polymerization and teimmation efficiency The polymers were analyzed in detail using NM R spectroscopy. size exclusion chromatography (SEC), and MALDI-Tor.MS Molecular weights of the sampks prepared ranged between 1800 and 9000 g/mol. For all of the novel termination agents full termination was confir Tied by MALDI-ToF MS The approach presented is applicable for a lame variety of monomers that are polymenzable by carbanionic polymerization

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