tert-Butyl δ-[(1,2-dihydro-1,2-dioxonaphth-4-yl)oxy]valerate | 305835-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-Butyl δ-[(1,2-dihydro-1,2-dioxonaphth-4-yl)oxy]valerate
• 英文别名: tert-Butyl delta-[(1,2-dihydro-1,2-dioxonaphth-4-yl)oxy]valerate；tert-butyl 5-(3,4-dioxonaphthalen-1-yl)oxypentanoate
• CAS: 305835-88-5
• 化学式: C₁₉H₂₂O₅
• 分子量: 330.381
• InChiKey: CWOKALSHEPTURB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-hydroxy-1,4-naphthoquinone silver salt 、 5-溴戊酸叔丁酯 以 甲醇 、 氯仿 、 苯 为溶剂， 以30%的产率得到tert-Butyl δ-[(1,2-dihydro-1,2-dioxonaphth-4-yl)oxy]valerate
  参考文献：
  名称：

  Quinones as disease therapies

  摘要：

  提供了新型喹喔醌，以及包含这些新型喹喔醌的组合物。还提供了使用这些新型喹喔醌治疗包括癌症在内的各种疾病的方法。

  公开号：

  US06482943B1

文献信息

• Novel quinones as disease therapies
  申请人：SLIL Biomedical Corporation

  公开号：US20020183512A1

  公开（公告）日：2002-12-05

  Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

  提供了新型喹喔醌，以及包含这些新型喹喔醌的组合物。还提供了使用这些新型喹喔醌治疗包括癌症在内的各种适应症的方法。
• QUINONES AS DISEASE THERAPIES
  申请人：——

  公开号：US20030013677A1

  公开（公告）日：2003-01-16

  Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

  本发明提供了新型的醌类化合物，以及包含这些新型醌类化合物的组合物。本发明还提供了使用这些新型醌类化合物治疗各种疾病，包括癌症的方法。
• Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
  申请人：SLIL Biomedical Corporation

  公开号：US20040006049A1

  公开（公告）日：2004-01-08

  Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.

  本发明提供了肽共轭物，其中将细胞毒性和细胞增殖抑制剂，如多胺类似物或萘醌类化合物，与被酶如前列腺特异性抗原（PSA）和半胱氨酸蛋白酶B识别和切割的多肽共轭。同时提供了包含这些共轭物的组合物。本发明还提供了使用这些共轭物治疗前列腺疾病的方法。
• Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
  申请人：SLIL Biomedical Corporation

  公开号：US06649587B1

  公开（公告）日：2003-11-18

  Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.

  提供了多肽偶联物，其中细胞毒性和细胞生长抑制剂，如多胺类似物或萘醌类化合物，与被酶类如前列腺特异性抗原（PSA）和半胱氨酸蛋白酶B识别和切割的多肽偶联，以及包含这些偶联物的组合物。同时还提供了使用这些偶联物治疗前列腺疾病的方法。