1-(1,2,2,3,3,4,4,5,5,6,6-Undecafluorocyclohexyl)ethanol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1-(1,2,2,3,3,4,4,5,5,6,6-Undecafluorocyclohexyl)ethanol
• 化学式: C₈H₅F₁₁O
• 分子量: 326.11
• InChiKey: SVQLLPOUSBWFHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  1-(1,2,2,3,3,4,4,5,5,6,6-Undecafluorocyclohexyl)ethanol 在 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis and Comparative Analysis of the Steric and Supramolecular Structures of Diastereomers of 4,4-Bis(trifluoromethyl)-2-(fluoroalkoxy)-6,7-benzo-1,3,2 ⁵- dioxaphosphepin-5-one 2-Oxides

  摘要：

  Reaction with hexafluoroacetone of 2-fluoroalkoxy-5,6-benzo-1,3,2-dioxophosphorinan-5-ones containing a chiral fluorinated exocyclic substituent on the phosphorus atom, with hexafluoroacetone leads to formation of 4,4-bis(trifluoromethyl)-6,7-benzo-1,4,2-dioxaphosphepines with a high regio- and stereoselectivity. The configuration of all isolated individual diastereomers was established by X-ray diffraction. The molecular and supramolecular structure of the compounds were examined in terms of the proposed model that takes account of the revealed effect of separation of hydrophilic and lipophilic regions in the crystal.

  DOI：

  10.1023/b:rugc.0000042419.00823.95

文献信息

• POLYCARBONATE-BASE POLYMER, PRODUCTION PROCESS, RESIN COATING FLUID PREPARED THEREFROM, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR PREPARED THEREFROM
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0837085A1

  公开（公告）日：1998-04-22

  A polymer comprising mainly repeating units (1) and/or repeating units (2), containing optionally terminal groups (3) and/or repeating units (4), and having a reduced viscosity [ηsp/c] of 0.2 to 10.0 dl/g as measured in a 0.5 g/dl solution thereof in methylene chloride at 20°C; a resin coating fluid containing the polymer, a charge-transfer substance and a solvent; and an electrophotographic photoreceptor containing the polymer as a binder resin in a photosensitive layer, wherein Rf1 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to the two oxygen atoms of the carbonate linkage in the general formula (1) without any intervening arylene group; and Rf2 represents a group that is composed of at least carbon atoms and fluorine atoms and bonded directly to one of the oxygen atoms of the carbonate linkage in the general formula (3) without any intervening arylene group.

  一种主要由重复单元（1）和/或重复单元（2）组成的聚合物，含有任选的末端基团（3）和/或重复单元（4），在 0.其中 Rf1 代表至少由碳原子和氟原子组成并直接与通式（1）中碳酸酯连接的两个氧原子键合的基团，而没有任何芳基介入；Rf2 代表一个至少由碳原子和氟原子组成的基团，直接与通式（3）中碳酸酯链节的一个氧原子键合，中间不含任何芳烯基。
• Compartmentalised combinatorial chemistry by microfluidic control
  申请人：Medical Research Council

  公开号：EP2556883A1

  公开（公告）日：2013-02-13

  The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

  本发明描述了一种合成化合物的方法，包括以下步骤(a) 将两组或两组以上的初级化合物分隔成微胶囊；使一定比例的微胶囊含有两种或两种以上的化合物；以及 (b) 通过来自不同组的初级化合物之间的化学反应在微胶囊中形成次级化合物；其中步骤(a)和步骤(b)中的一个或两个是在微流体控制下进行的；最好是电子微流体控制。本发明还可进一步鉴定与生化系统的目标成分结合或调节目标活性的化合物，并将其共同分装到微胶囊中。
• Compartmentalised screening by microfluidic control
  申请人：Medical Research Council

  公开号：EP2602018A1

  公开（公告）日：2013-06-12

  The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

  本发明描述了一种用于鉴定与生化系统的目标成分结合或调节目标活性的化合物的方法，包括以下步骤：a) 将化合物与目标成分一起分隔到微胶囊中，这样在任何一个微胶囊中都只有一个子集的化合物以多个拷贝的形式存在；b) 鉴定与目标成分结合或调节目标活性的化合物；其中至少有一个步骤是在微流体控制下进行的。本发明可以筛选出大量分子，作为药物开发的线索。
• Method for handling and mixing droplets
  申请人：President and Fellows of Harvard College

  公开号：EP2662136A2

  公开（公告）日：2013-11-13

  Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.

  本发明的各个方面涉及流体种类的控制和操纵，例如在微流体系统中。在一个方面，本发明涉及利用电场、机械改变、添加中间流体等方法制造被液体包围的液滴的系统和方法。在某些情况下，液滴中每个实体的数量基本一致。例如，95% 或更多的液滴可能各自含有相同数量的特定种类的实体。在另一方面，本发明涉及将流体液滴分成两个液滴的系统和方法，例如，通过电荷和/或偶极子与电场的相互作用。本发明还涉及根据本发明的另一方面，例如通过电荷和/或偶极子相互作用将液滴融合的系统和方法。在某些情况下，液滴的融合可引发或决定反应。在本发明的一个相关方面，还提供了允许液滴内发生流体混合的系统和方法。在另一个方面，本发明涉及用于分选液滴的系统和方法，例如，通过使液滴移动到流体系统内的某些区域。例子包括使用电相互作用（如电荷、偶极子等）或机械系统（如流体位移）来分选液滴。在某些情况下，流体液滴可以相对较高的速度分选，例如每秒分选约 10 个液滴或更多。本发明的另一方面提供了确定液滴或其组分的能力，例如，使用荧光和/或其他光学技术（如显微镜），或电传感技术（如介电传感）。
• Method for mixing droplets in a microchannel
  申请人：President and Fellows of Harvard College

  公开号：EP2662135A2

  公开（公告）日：2013-11-13

  Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.

  本发明的各个方面涉及流体种类的控制和操纵，例如在微流体系统中。在一个方面，本发明涉及利用电场、机械改变、添加中间流体等方法制造被液体包围的液滴的系统和方法。在某些情况下，液滴中每个实体的数量基本一致。例如，95% 或更多的液滴可能各自含有相同数量的特定种类的实体。在另一方面，本发明涉及将流体液滴分成两个液滴的系统和方法，例如，通过电荷和/或偶极子与电场的相互作用。本发明还涉及根据本发明的另一方面，例如通过电荷和/或偶极子相互作用将液滴融合的系统和方法。在某些情况下，液滴的融合可引发或决定反应。在本发明的一个相关方面，还提供了允许液滴内发生流体混合的系统和方法。在另一个方面，本发明涉及用于分选液滴的系统和方法，例如，通过使液滴移动到流体系统内的某些区域。例子包括使用电相互作用（如电荷、偶极子等）或机械系统（如流体位移）来分选液滴。在某些情况下，流体液滴可以相对较高的速度分选，例如每秒分选约 10 个液滴或更多。本发明的另一方面提供了确定液滴或其组分的能力，例如，使用荧光和/或其他光学技术（如显微镜），或电传感技术（如介电传感）。