2-[3-(Diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-(2-methylsulfonylsulfanylethylazaniumyl)sulfonylbenzenesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[3-(Diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-(2-methylsulfonylsulfanylethylazaniumyl)sulfonylbenzenesulfonate
• 英文别名: 2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-(2-methylsulfonylsulfanylethylazaniumyl)sulfonylbenzenesulfonate
• 化学式: C30H38N3O8S4+
• 分子量: 696.9
• InChiKey: DZJCGEWZGVLAEE-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  45
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  201
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Imaging and therapeutic method using monocytes
  申请人：Low S. Philip

  公开号：US20070009434A1

  公开（公告）日：2007-01-11

  The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group A b comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.

  本发明涉及一种治疗或诊断由单核细胞介导的疾病状态的方法。该方法利用包含一种复合物或复合物的组合物，其一般公式为Ab-X的组合物，其中Ab组含与单核细胞结合的配体，当该复合物用于治疗疾病状态时，组X包含免疫原、细胞毒素或能够改变单核细胞功能的化合物，当该复合物用于诊断疾病状态时，组X包含成像剂。
• IMAGING AND THERAPEUTIC METHOD USING PROGENITOR CELLS
  申请人：Low Philip Stewart

  公开号：US20100226967A1

  公开（公告）日：2010-09-09

  The invention relates to a method of treating or diagnosing a disease state worsened by progenitor cells. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group A b comprises a vitamin, or an analog thereof, that binds to progenitor cells, and when the conjugate is being used for treatment of the disease state, the group X comprises an antigen, a cytotoxin, or a compound capable of altering progenitor cell function, and when the conjugate is being used for diagnosing the disease state, the group X comprises a quantifiable marker.

  本发明涉及一种治疗或诊断由祖细胞恶化引起的疾病状态的方法。该方法利用包含通式Ab-X的共轭物或复合物的组合物，其中Ab组包括维生素或其类似物，该维生素或其类似物与祖细胞结合。当该共轭物用于治疗疾病状态时，组X包括抗原、细胞毒素或能够改变祖细胞功能的化合物；当该共轭物用于诊断疾病状态时，组X包括可量化的标记物。
• METHOD OF DETECTING ENDOTHELIAL PROGENITOR CELLS
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20130266964A1

  公开（公告）日：2013-10-10

  A method of detecting endothelial progenitor cells is provided. The method involves contacting a population of cells with a composition comprising a conjugate or complex of the formula A b -X where the group A b comprises a folate that binds to endothelial progenitor cells, and the group X comprises a fluorescent chromophore, and eliciting a fluorescent response from bound A b -X.

  提供了一种检测内皮祖细胞的方法。该方法涉及将细胞群体与包含式Ab-X的共轭物或复合物的组合物接触，其中组Ab包括结合内皮祖细胞的叶酸，组X包括荧光色团，并从结合的Ab-X中引出荧光响应。
• IMAGING AND THERAPEUTIC METHOD USING MONOCYTES
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20140065066A1

  公开（公告）日：2014-03-06

  The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group A b comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.

  本发明涉及一种治疗或诊断由单核细胞介导的疾病状态的方法。该方法利用包含以下通式Ab-X的共轭物或复合物的组合物，其中Ab组包括结合单核细胞的配体，当共轭物用于治疗疾病状态时，组X包括免疫原、细胞毒素或能够改变单核细胞功能的化合物，当共轭物用于诊断疾病状态时，组X包括成像剂。
• Imaging and Therapeutic Method Using Monocytes
  申请人：Low Philip S.

  公开号：US20090214636A1

  公开（公告）日：2009-08-27

  The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula A b -X wherein the group A b comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.

  本发明涉及一种治疗或诊断由单核细胞介导的疾病状态的方法。该方法利用包含一种一般式为Ab-X的共轭物或复合物的组合物，其中Ab组包含结合单核细胞的配体，当该共轭物用于治疗疾病状态时，组X包含免疫原、细胞毒素或能够改变单核细胞功能的化合物；当该共轭物用于诊断疾病状态时，组X包含成像剂。