1-ethyl-3-(2-hydroxy-1-(hydroxymethyl)ethyl)urea | 1346041-65-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-ethyl-3-(2-hydroxy-1-(hydroxymethyl)ethyl)urea
• 英文别名: 1-(1,3-Dihydroxypropan-2-yl)-3-ethylurea
• CAS: 1346041-65-3
• 化学式: C₆H₁₄N₂O₃
• 分子量: 162.189
• InChiKey: BQOCRWFHVSMTSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  81.6
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丝氨醇 、 异氰酸乙酯 以 四氢呋喃 、 甲醇 为溶剂， 反应 5.0h， 生成 1-ethyl-3-(2-hydroxy-1-(hydroxymethyl)ethyl)urea
  参考文献：
  名称：

  Tunable Thermoplastic Poly(ester–urethane)s Based on Modified Serinol Extenders

  摘要：

  As a consequence of their mechanical properties, thermoplastic poly(ester-urethane)s (TPEUs) have been extensively examined for their potential applications in biomedical engineering. The incorporation of bio-derived small molecules, such as amino acid derivatives, as chain extenders may allow for more biodegradable hard segments, which result in nontoxic degradants. TPEUs were synthesized using modified 2-aminopropane-1,3-diol (serinol) extenders, ethyl (1,3-dihydroxypropan-2-yl)carbamate (C-3c), and 1-(1,3-dihydroxypropan-2-yl)-3-ethylurea (C-3u) in order to determine the effect of extender side group functionality on the properties of the resultant materials. The TPEUs were synthesized with varying percentage "hard" segment (%HS) using poly(e-caprolactone) (PCL) and 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane (H12MDI) as the polyol and diisocyanate, respectively. It was found that by controlling the %HS and side group functionality, the thermal and mechanical properties of the materials could be tuned. Furthermore, the selection of extender was

  DOI：

  10.1021/acs.macromol.5b02531

文献信息

• Carbonyl-Inserted Organo-Hybrids of a Dawson-Type Phosphovanadotungstate: Scope and Chemoselective Oxidation Catalysis
  作者：Julie Oble、Benoît Riflade、Amandine Noël、Max Malacria、Serge Thorimbert、Bernold Hasenknopf、Emmanuel Lacôte

  DOI：10.1021/ol202430e

  日期：2011.11.18

  The Dawson-type polyoxometalate (POM) [P2V3W15O62](9-) is a prototype for inclusion of carbonyls of amides, ureas, carbamates, and thiocarbamates into polyoxometallic structures. The carbonyl-inserted POMs catalyze the oxidation of sulfides. Chemoselectivity depends primarily on the proton content of the POM, but it Is also influenced by the organic substituent.
• Tunable Thermoplastic Poly(ester–urethane)s Based on Modified Serinol Extenders
  作者：Ruairí P. Brannigan、Anthony Walder、Andrew P. Dove

  DOI：10.1021/acs.macromol.5b02531

  日期：2016.4.12

  As a consequence of their mechanical properties, thermoplastic poly(ester-urethane)s (TPEUs) have been extensively examined for their potential applications in biomedical engineering. The incorporation of bio-derived small molecules, such as amino acid derivatives, as chain extenders may allow for more biodegradable hard segments, which result in nontoxic degradants. TPEUs were synthesized using modified 2-aminopropane-1,3-diol (serinol) extenders, ethyl (1,3-dihydroxypropan-2-yl)carbamate (C-3c), and 1-(1,3-dihydroxypropan-2-yl)-3-ethylurea (C-3u) in order to determine the effect of extender side group functionality on the properties of the resultant materials. The TPEUs were synthesized with varying percentage "hard" segment (%HS) using poly(e-caprolactone) (PCL) and 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane (H12MDI) as the polyol and diisocyanate, respectively. It was found that by controlling the %HS and side group functionality, the thermal and mechanical properties of the materials could be tuned. Furthermore, the selection of extender was